Rome2Rio

How to get fromPanama City Beach to Des Moinesby plane, bus (Greyhound, Flixbus, Amtrak), bus, train, car, or bus (Greyhound, Flixbus)

Find Transport to Des Moines

See all options

There are 8 ways to get from Panama City Beach to Des Moines by plane, bus (Greyhound, Flixbus, Amtrak), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Northwest Florida Beaches International Airport

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Des Moines (DSM)plane plane ECP - DSM
    5h 19m
    $221–835

  2. Drive to Destin–Fort Walton Beach Airport, fly

    cheapest
    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM)plane plane VPS - DSM
    6h 18m
    $178–787

  3. Bus via Atlanta

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Carbondale Intermodal Stationbus bus
    4. Take the bus from Carbondale to St. Louisbus bus
    5. Take the bus from St Louis Bus Station to Des Moinesbus bus
    31h 30m
    $210–426

  4. Bus, train via New Orleans

    1. Take the bus from Panama City Beach Bus Station to Mobile Bus Stationbus bus
    2. Take the bus from Mobile Bus Station to New Orleans Bus Stationbus bus
    3. Take the train from New Orleans Union Passenger Terminal to Champaign-Urbanatrain train
    4. Take the bus from Champaign Intermodal Trans Ctr to Des Moinesbus bus
    33h 59m
    $365–756

  5. Drive 1,063.1 mi

    1. Drive from Panama City Beach to Des Moinescar car 1,063.1 mi
    19h 51m
    $194–281

  6. Drive to Dothan Regional Airport, fly

    1. Drive from Panama City Beach to Dothan Regional Airport (DHN)car car
    2. Fly from Dothan Regional Airport (DHN) to Des Moines (DSM)plane plane DHN - DSM
    6h 56m
    $184–796

  7. Bus

    1. Take the bus from Panama City Beach Bus Station to Mobile Bus Stationbus bus
    2. Take the bus from Mobile Bus Station to New Orleans Bus Stationbus bus
    3. Take the bus from New Orleans Bus Station to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Des Moinesbus bus
    32h 44m
    $215–436

  8. Bus, train

    1. Take the bus from Panama City Beach Bus Station to Jacksonvillebus bus
    2. Take the train from Jacksonville to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    2d 3h
    $601–1,294

Northwest Florida Beaches International Airport (ECP) to Des Moines (DSM) flights

Calendar78Weekly Planes
Duration6h 30mAverage Duration
Ticket$157Cheapest Price
See schedules

Questions & Answers

Map of how to get from Panama City Beach to Des Moines.ExpandLaunch map view
  • Distance: 912.4 mi
  • Duration: 5h 19m

What companies run services between Panama City Beach, FL, USA and Des Moines, IA, USA?

Delta, American Airlines, and two other airlines fly from Northwest Florida Beaches International Airport (ECP) to Des Moines (DSM) every 2 hours. Alternatively, you can take a vehicle from Panama City Beach to Des Moines via Panama City Beach Bus Station, Tallahassee, Atlanta Bus Station, Carbondale, St. Louis, and St Louis Bus Station in around 31h 30m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers