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How to get fromPanama City Beach to Florida Keysby plane, bus (Greyhound, Flixbus), car, bus, shuttle, or train

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There are 8 ways to get from Panama City Beach to Florida Keys by plane, bus (Greyhound, Flixbus), car, bus, shuttle, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Northwest Florida Beaches International Airport to Key West International Airport

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW)plane plane ECP - EYW
    7h 44m
    $201–508

  2. Bus

    cheapest
    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    19h 29m
    $123–240

  3. Drive 691.4 mi

    1. Drive from Panama City Beach to Florida Keyscar car 691.4 mi
    13h 38m
    $127–183

  4. Drive to Destin–Fort Walton Beach Airport, fly to Key West International Airport

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW)plane plane VPS - EYW
    8h 25m
    $143–420

  5. Bus to Tallahassee, fly to Key West International Airport

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Fly from Tallahassee (TLH) to Key West International Airport (EYW)plane plane TLH - EYW
    10h 2m
    $182–479

  6. Drive to Destin–Fort Walton Beach Airport, fly to Miami International Airport, shuttle

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane plane VPS - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 37m
    $223–530

  7. Bus, shuttle

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee FSU to Miami Airportbus bus
    3. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    19h 38m
    $300–472

  8. Bus, train

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Jacksonvillebus bus
    3. Take the train from Jacksonville to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    24h 19m
    $224–437

Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW) flights

Calendar36Weekly Planes
Duration6h 9mAverage Duration
Ticket$73Cheapest Price
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Questions & Answers

Map of how to get from Panama City Beach to Florida Keys.ExpandLaunch map view
  • Distance: 510.9 mi
  • Duration: 7h 44m

What companies run services between Panama City Beach, FL, USA and Florida Keys, FL, USA?

Delta and American Airlines fly from Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW) 5 times a day. Alternatively, you can take a vehicle from Panama City Beach to Florida Keys via Panama City Beach Bus Station, Tallahassee, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 19h 29m.

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