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How to get fromPanama City Beach to Gainesvilleby bus (Greyhound, Flixbus), car, plane, bus (Greyhound), or bus

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There are 7 ways to get from Panama City Beach to Gainesville by bus (Greyhound, Flixbus), car, plane, bus (Greyhound), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus Greyhound US0799 / ...
    2. Take the bus from Tallahassee to Gainesvillebus bus FlixBus 2410
    6h 9m
    $49–86

  2. Drive 243.4 mi

    cheapest
    1. Drive from Panama City Beach to Gainesvillecar car 243.4 mi
    4h 58m
    $45–65

  3. Fly Northwest Florida Beaches International Airport to Gainesville Regional Airport

    1. Fly from Northwest Florida Beaches International Airport (ECP) to Gainesville Regional Airport (GNV)plane plane ECP - GNV
    5h 36m
    $116–426

  4. Bus via University of Florida - 1956 Gale Lemerand Dr

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus Greyhound US0799 / ...
    2. Take the bus from Tallahassee - FSU - Old St Augustine at Intramural Field to University of Florida - 1956 Gale Lemerand Drbus bus Tallahassee
    6h 47m
    $62–113

  5. Drive to Destin–Fort Walton Beach Airport, fly to Gainesville Regional Airport

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Gainesville Regional Airport (GNV)plane plane VPS - GNV
    7h 8m
    $78–378

  6. Drive to Dothan Regional Airport, fly to Gainesville Regional Airport

    1. Drive from Panama City Beach to Dothan Regional Airport (DHN)car car
    2. Fly from Dothan Regional Airport (DHN) to Gainesville Regional Airport (GNV)plane plane DHN - GNV
    8h 45m
    $79–367

  7. Fly Northwest Florida Beaches International Airport to Jacksonville, bus

    1. Fly from Northwest Florida Beaches International Airport (ECP) to Jacksonville (JAX)plane plane ECP - JAX
    2. Take the bus from Jacksonville to Gainesvillebus bus
    7h 48m
    $136–476

Northwest Florida Beaches International Airport (ECP) to Gainesville Regional Airport (GNV) flights

Calendar55Weekly Planes
Duration5h 42mAverage Duration
Ticket$64Cheapest Price
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Questions & Answers

Map of how to get from Panama City Beach to Gainesville.ExpandLaunch map view
  • Distance: 254.5 mi
  • Duration: 6h 9m

What companies run services between Panama City Beach, FL, USA and Gainesville, FL, USA?

You can take a vehicle from Panama City Beach to Gainesville via Panama City Beach Bus Station and Tallahassee in around 6h 9m. Alternatively, Delta and American Airlines fly from Northwest Florida Beaches International Airport (ECP) to Gainesville Regional Airport (GNV) every 4 hours.

Airlines
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