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How to get fromPanama City Beach to Great Smoky Mountainsby plane, car, bus, or train

Find Transport to Great Smoky Mountains

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There are 7 ways to get from Panama City Beach to Great Smoky Mountains by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Northwest Florida Beaches International Airport to Mcghee Tyson Airport, drive

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Mcghee Tyson Airport (TYS)plane plane ECP - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    5h 18m
    $164–730

  2. Drive to Destin–Fort Walton Beach Airport, fly to Asheville Regional Airport, drive

    cheapest
    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Asheville Regional Airport (AVL)plane plane VPS - AVL
    3. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    6h 55m
    $80–368

  3. Bus, drive

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    22h 33m
    $144–286

  4. Drive 477.6 mi

    1. Drive from Panama City Beach to Great Smoky Mountainscar car 477.6 mi
    9h 24m
    $88–126

  5. Fly Northwest Florida Beaches International Airport to Asheville Regional Airport, drive

    1. Fly from Northwest Florida Beaches International Airport (ECP) to Asheville Regional Airport (AVL)plane plane ECP - AVL
    2. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    5h 54m
    $118–416

  6. Drive to Destin–Fort Walton Beach Airport, fly to Mcghee Tyson Airport, drive

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS)plane plane VPS - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    4h 38m
    $121–682

  7. Bus, train, drive

    1. Take the bus from Panama City Beach Bus Station to Jacksonvillebus bus
    2. Take the train from Jacksonville to Carytrain train
    3. Take the train from Cary to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    27h 11m
    $251–524

Northwest Florida Beaches International Airport (ECP) to Mcghee Tyson Airport (TYS) flights

Calendar63Weekly Planes
Duration4h 18mAverage Duration
Ticket$105Cheapest Price
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Questions & Answers

Map of how to get from Panama City Beach to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 468.6 mi
  • Duration: 5h 18m

What companies run services between Panama City Beach, FL, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Panama City Beach to Great Smoky Mountains. However, you can take the taxi to Northwest Florida Beaches International Airport (ECP) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a vehicle from Panama City Beach to Great Smoky Mountains via Panama City Beach Bus Station, Tallahassee, Atlanta Bus Station, Winston Salem(Trans Center), and Asheville, NC in around 22h 33m.

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