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How to get fromPanama City Beach to Greenvilleby plane, bus (Greyhound, Flixbus), car, or taxi

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There are 5 ways to get from Panama City Beach to Greenville by plane, bus (Greyhound, Flixbus), car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Northwest Florida Beaches International Airport to Greenville–Spartanburg International Airport

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Greenville–Spartanburg International Airport (GSP)plane plane ECP - GSP
    4h 7m
    $164–589

  2. Drive 437.7 mi

    cheapest
    1. Drive from Panama City Beach to Greenvillecar car 437.7 mi
    7h 57m
    $80–116

  3. Bus

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    15h 12m
    $116–195

  4. Fly Northwest Florida Beaches International Airport to Asheville Regional Airport, taxi

    1. Fly from Northwest Florida Beaches International Airport (ECP) to Asheville Regional Airport (AVL)plane plane ECP - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    4h 49m
    $244–564

  5. Drive to Destin–Fort Walton Beach Airport, fly to Greenville–Spartanburg International Airport

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Greenville–Spartanburg International Airport (GSP)plane plane VPS - GSP
    4h 57m
    $126–541

Northwest Florida Beaches International Airport (ECP) to Greenville–Spartanburg International Airport (GSP) flights

Calendar74Weekly Planes
Duration4h 25mAverage Duration
Ticket$78Cheapest Price
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Questions & Answers

Map of how to get from Panama City Beach to Greenville.ExpandLaunch map view
  • Distance: 407 mi
  • Duration: 4h 7m

What companies run services between Panama City Beach, FL, USA and Greenville, SC, USA?

Delta, Southwest Airlines, and two other airlines fly from Northwest Florida Beaches International Airport (ECP) to Greenville–Spartanburg International Airport (GSP) every 2 hours. Alternatively, you can take a vehicle from Panama City Beach to Greenville via Panama City Beach Bus Station, Tallahassee, Atlanta Bus Station, Garnett Station, Lindbergh Center Station, Lindbergh Center Station - Bay D, Shallowford Rd @ New Peachtree, Atlanta, and Taqueria Guadalajara - Greenville in around 15h 12m.

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