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How to get fromPanama City Beach to Key Largoby car, plane, shuttle, bus, train, or bus (Greyhound, Flixbus)

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There are 10 ways to get from Panama City Beach to Key Largo by car, plane, shuttle, bus, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Destin–Fort Walton Beach Airport, fly to Miami International Airport, shuttle

    best
    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane plane VPS - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    5h 27m
    $171–516

  2. Bus, train

    cheapest
    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Ft Lauderdale Broward Park & Ridebus bus
    3. Take the train from Fort Lauderdale Station to Miami Airport Stationtrain train
    4. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    16h 18m
    $103–167

  3. Bus, shuttle

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee - FSU - Old St Augustine at Intramural Field to Miami Airportbus bus
    3. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    15h 52m
    $248–339

  4. Bus, train via Jacksonville

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Jacksonvillebus bus
    3. Take the train from Jacksonville to Hollywood Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    20h 8m
    $174–343

  5. Drive  609.7 mi

    1. Drive from Panama City Beach to Key Largocar car 609.7 mi
    11h 45m
    $112–161

  6. Fly Northwest Florida Beaches International Airport to Miami International Airport, shuttle

    1. Fly from Northwest Florida Beaches International Airport (ECP) to Miami International Airport (MIA)plane plane ECP - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    6h 40m
    $239–634

  7. Fly Northwest Florida Beaches International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Northwest Florida Beaches International Airport (ECP) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane ECP - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FLshuttle bus
    7h 15m
    $259–674

  8. Bus to Tallahassee, fly to Miami International Airport, shuttle

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Fly from Tallahassee (TLH) to Miami International Airport (MIA)plane plane TLH - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    7h 24m
    $225–676

  9. Bus to Pensacola International Airport, fly to Miami International Airport, shuttle

    1. Take the bus from Panama City Beach Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Miami International Airport (MIA)plane plane PNS - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    7h 41m
    $185–516

  10. Bus

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    18h 54m
    $114–191

Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA) flights

Calendar27Weekly Planes
Duration3h 46mAverage Duration
Ticket$64Cheapest Price
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Comparing Your Travel Options

Map of how to get from Panama City Beach to Key Largo.ExpandLaunch map view
  • Distance: 617.9 mi
  • Duration: 5h 27m

What companies run services between Panama City Beach, FL, USA and Key Largo, FL, USA?

You can take a vehicle from Panama City Beach to Key Largo Bus Stop via Panama City Beach Bus Station, Tallahassee, and Miami Airport Station in around 18h 54m.

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Train operators
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