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How to get fromPanama City Beach to Key Largoby plane, shuttle, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

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There are 10 ways to get from Panama City Beach to Key Largo by plane, shuttle, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Northwest Florida Beaches International Airport to Miami International Airport, shuttle

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Miami International Airport (MIA)plane plane ECP - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    7h 8m
    $234–594

  2. Drive 609.7 mi

    cheapest
    1. Drive from Panama City Beach to Key Largocar car 609.7 mi
    11h 45m
    $112–161

  3. Bus

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee FSU to Miami Airportbus bus
    3. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    16h 21m
    $186–338

  4. Bus, train

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Jacksonvillebus bus
    3. Take the train from Jacksonville to Hollywood Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    20h 50m
    $233–430

  5. Drive to Destin–Fort Walton Beach Airport, fly to Miami International Airport, shuttle

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane plane VPS - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    5h 22m
    $171–476

  6. Fly Northwest Florida Beaches International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Northwest Florida Beaches International Airport (ECP) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane ECP - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FLshuttle bus
    7h 17m
    $259–634

  7. Bus to Tallahassee, fly to Miami International Airport, shuttle

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Fly from Tallahassee (TLH) to Miami International Airport (MIA)plane plane TLH - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    7h 28m
    $219–550

  8. Bus to Pensacola International Airport, fly to Miami International Airport, shuttle

    1. Take the bus from Panama City Beach Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Miami International Airport (MIA)plane plane PNS - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    7h 47m
    $180–471

  9. Bus via Homestead

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Ft Lauderdale Broward Park & Ridebus bus
    3. Take the bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largobus bus 301
    17h 23m
    $127–206

  10. Bus #2

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    18h 54m
    $149–266

Northwest Florida Beaches International Airport (ECP) to Miami International Airport (MIA) flights

Calendar84Weekly Planes
Duration5h 44mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

Map of how to get from Panama City Beach to Key Largo.ExpandLaunch map view
  • Distance: 536.4 mi
  • Duration: 7h 8m

What companies run services between Panama City Beach, FL, USA and Key Largo, FL, USA?

You can take a vehicle from Panama City Beach to Key Largo Bus Stop via Panama City Beach Bus Station, C.K. Steele Plaza Gate 21, Varsity at Saint Agustine, Tallahassee FSU, Miami Airport, Miami International Airport, Miami, Airport Intermodal Station, and Miami Airport Station in around 16h 21m.

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