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How to get fromPanama City Beach to Key Westby plane, bus, ferry, car, shuttle, or bus (Greyhound, Flixbus)

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There are 9 ways to get from Panama City Beach to Key West by plane, bus, ferry, car, shuttle, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Northwest Florida Beaches International Airport

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW)plane plane ECP - EYW
    4h 57m
    $135–427

  2. Drive to Destin–Fort Walton Beach Airport, fly

    cheapest
    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW)plane plane VPS - EYW
    5h 38m
    $77–339

  3. Bus, ferry

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Fort Myersbus bus
    3. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    17h 36m
    $288–348

  4. Drive 706.9 mi

    1. Drive from Panama City Beach to Key Westcar car 706.9 mi
    14h 1m
    $129–187

  5. Drive to Dothan Regional Airport, fly

    1. Drive from Panama City Beach to Dothan Regional Airport (DHN)car car
    2. Fly from Dothan Regional Airport (DHN) to Key West International Airport (EYW)plane plane DHN - EYW
    6h 51m
    $93–378

  6. Bus to Tallahassee, fly

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Fly from Tallahassee (TLH) to Key West International Airport (EYW)plane plane TLH - EYW
    7h 16m
    $116–398

  7. Bus to Pensacola International Airport, fly

    1. Take the bus from Panama City Beach Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Key West International Airport (EYW)plane plane PNS - EYW
    7h 41m
    $86–334

  8. Bus, shuttle

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee FSU to Miami Airportbus bus
    3. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus
    20h 1m
    $320–492

  9. Bus

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    20h 16m
    $123–240

Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW) flights

Calendar36Weekly Planes
Duration6h 9mAverage Duration
Ticket$73Cheapest Price
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Questions & Answers

Map of how to get from Panama City Beach to Key West.ExpandLaunch map view
  • Distance: 491.7 mi
  • Duration: 4h 57m

What companies run services between Panama City Beach, FL, USA and Key West, FL, USA?

Delta and American Airlines fly from Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW) 5 times a day. Alternatively, you can take a vehicle from Panama City Beach to N Roosevelt & 3rd Street via Panama City Beach Bus Station, Tallahassee, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 20h 16m.

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