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How to get fromPanama City Beach to Knoxvilleby plane, bus, train, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Panama City Beach to Knoxville by plane, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Northwest Florida Beaches International Airport

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Mcghee Tyson Airport (TYS)plane plane ECP - TYS
    3h 43m
    $204–734

  2. Drive 479.4 mi

    cheapest
    1. Drive from Panama City Beach to Knoxvillecar car 479.4 mi
    9h 14m
    $88–127

  3. Bus, train via Farragut

    1. Take the bus from Panama City Beach Bus Station to Jacksonvillebus bus
    2. Take the train from Jacksonville to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    40h 52m
    $544–997

  4. Drive to Destin–Fort Walton Beach Airport, fly

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS)plane plane VPS - TYS
    3h 3m
    $161–686

  5. Drive to Dothan Regional Airport, fly

    1. Drive from Panama City Beach to Dothan Regional Airport (DHN)car car
    2. Fly from Dothan Regional Airport (DHN) to Mcghee Tyson Airport (TYS)plane plane DHN - TYS
    5h 13m
    $157–645

  6. Bus, train

    1. Take the bus from Panama City Beach Bus Station to Jacksonvillebus bus
    2. Take the train from Jacksonville to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 56m
    $499–907

  7. Bus

    1. Take the bus from Panama City Beach Bus Station to Jacksonvillebus bus
    2. Take the bus from Jacksonville to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    43h 25m
    $309–476

Northwest Florida Beaches International Airport (ECP) to Mcghee Tyson Airport (TYS) flights

Calendar64Weekly Planes
Duration4h 18mAverage Duration
Ticket$96Cheapest Price
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Questions & Answers

Map of how to get from Panama City Beach to Knoxville.ExpandLaunch map view
  • Distance: 422.2 mi
  • Duration: 3h 43m

What companies run services between Panama City Beach, FL, USA and Knoxville, TN, USA?

Delta, Southwest Airlines, and American Airlines fly from Northwest Florida Beaches International Airport (ECP) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a vehicle from Panama City Beach to Knoxville Station Hall of Fame via Panama City Beach Bus Station, Jacksonville, New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 43h 25m.

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