Rome2Rio

How to get fromPanama City Beach to Lexingtonby plane, car, or bus

Find Transport to Lexington

See all options

There are 10 ways to get from Panama City Beach to Lexington by plane, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Northwest Florida Beaches International Airport to Louisville International Airport, drive

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Louisville International Airport (SDF)plane plane ECP - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    5h 12m
    $158–635

  2. Drive to Destin–Fort Walton Beach Airport, fly to Louisville International Airport, drive

    cheapest
    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Louisville International Airport (SDF)plane plane VPS - SDF
    3. Drive from Louisville-Airport-SDF to Lexingtoncar car
    4h 37m
    $115–587

  3. Bus, drive via Newburg

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    3. Take the bus from Tornado Bus Co - Nashville to La Tropicana - Louisville, KYbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    22h 18m
    $165–364

  4. Drive 637 mi

    1. Drive from Panama City Beach to Lexingtoncar car 637 mi
    12h 8m
    $117–168

  5. Fly Northwest Florida Beaches International Airport to Blue Grass Airport

    1. Fly from Northwest Florida Beaches International Airport (ECP) to Blue Grass Airport (LEX)plane plane ECP - LEX
    6h 28m
    $186–816

  6. Drive to Destin–Fort Walton Beach Airport, fly to Covington, drive

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Covington (CVG)plane plane VPS - CVG
    3. Drive from Covington (CVG) to Lexingtoncar car
    4h 47m
    $126–638

  7. Drive to Destin–Fort Walton Beach Airport, fly to Blue Grass Airport

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Blue Grass Airport (LEX)plane plane VPS - LEX
    7h 12m
    $143–768

  8. Bus, drive

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    22h 49m
    $144–265

  9. Bus, drive via Evansville

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Evansville Bus Stationbus bus
    4. Take the bus from Evansville, IN to Corydon, INbus bus
    5. Drive from Middletown Station @ Target to Lexingtoncar car
    23h 59m
    $226–382

  10. Bus, drive via Atlanta

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Evansville Bus Stationbus bus
    4. Take the bus from Evansville, IN to Corydon, INbus bus
    5. Drive from Middletown Station @ Target to Lexingtoncar car
    26h 5m
    $229–390

Northwest Florida Beaches International Airport (ECP) to Louisville International Airport (SDF) flights

Calendar73Weekly Planes
Duration4h 37mAverage Duration
Ticket$94Cheapest Price
See schedules

Questions & Answers

Map of how to get from Panama City Beach to Lexington.ExpandLaunch map view
  • Distance: 639 mi
  • Duration: 5h 12m

What companies run services between Panama City Beach, FL, USA and Lexington, KY, USA?

Delta, American Airlines, and United Airlines fly from Northwest Florida Beaches International Airport (ECP) to Blue Grass Airport (LEX) every 3 hours.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound