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How to get fromPanama City Beach to Lexingtonby plane, bus (Greyhound), or car

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There are 4 ways to get from Panama City Beach to Lexington by plane, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Northwest Florida Beaches International Airport

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Columbia (CAE)plane plane ECP - CAE
    4h 38m
    $222–949

  2. Drive 418.2 mi

    cheapest
    1. Drive from Panama City Beach to Lexingtoncar car 418.2 mi
    8h 50m
    $77–111

  3. Bus

    1. Take the bus from Panama City Beach Bus Station to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Camdenbus bus
    3. Take the bus from Camden to Columbia, SCbus bus Nyc
    16h 44m
    $158–271

  4. Drive to Destin–Fort Walton Beach Airport, fly

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Columbia (CAE)plane plane VPS - CAE
    5h
    $179–901

Northwest Florida Beaches International Airport (ECP) to Columbia (CAE) flights

Calendar72Weekly Planes
Duration5hAverage Duration
Ticket$144Cheapest Price
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Questions & Answers

Map of how to get from Panama City Beach to Lexington.ExpandLaunch map view
  • Distance: 396.1 mi
  • Duration: 4h 38m

What companies run services between Panama City Beach, FL, USA and Lexington, SC, USA?

American Airlines, Delta, and United Airlines fly from Northwest Florida Beaches International Airport (ECP) to Columbia (CAE) every 3 hours. Alternatively, you can take a vehicle from Panama City Beach to Lexington via Panama City Beach Bus Station, Jacksonville, Camden, and Columbia, SC in around 16h 44m.

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