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How to get fromPanama City Beach to Louisvilleby plane, bus (Greyhound, Amtrak), car, or bus (Greyhound)

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There are 6 ways to get from Panama City Beach to Louisville by plane, bus (Greyhound, Amtrak), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Northwest Florida Beaches International Airport to Louisville International Airport

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Louisville International Airport (SDF)plane plane ECP - SDF
    4h 54m
    $145–617

  2. Drive to Destin–Fort Walton Beach Airport, fly to Louisville International Airport

    cheapest
    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Louisville International Airport (SDF)plane plane VPS - SDF
    4h 21m
    $102–569

  3. Bus

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    18h 19m
    $125–241

  4. Drive 629.9 mi

    1. Drive from Panama City Beach to Louisvillecar car 629.9 mi
    11h 4m
    $115–166

  5. Drive to Destin–Fort Walton Beach Airport, fly to Blue Grass Airport, drive

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Blue Grass Airport (LEX)plane plane VPS - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 7m
    $154–785

  6. Bus via Preston @ Vim

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    3. Take the bus from Tornado Bus Co - Nashville to La Tropicana - Louisville, KYbus bus
    19h 11m
    $148–346

Northwest Florida Beaches International Airport (ECP) to Louisville International Airport (SDF) flights

Calendar74Weekly Planes
Duration4h 36mAverage Duration
Ticket$94Cheapest Price
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Questions & Answers

Map of how to get from Panama City Beach to Louisville.ExpandLaunch map view
  • Distance: 565.6 mi
  • Duration: 4h 54m

What companies run services between Panama City Beach, FL, USA and Louisville, KY, USA?

Southwest Airlines, Delta, and American Airlines fly from Northwest Florida Beaches International Airport (ECP) to Louisville International Airport (SDF) every 2 hours. Alternatively, you can take a vehicle from Panama City Beach to Louisville, KY via Panama City Beach Bus Station, Tallahassee, and Nashville in around 18h 19m.

Airlines
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