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How to get fromPanama City Beach to Port Saint Lucieby bus (Greyhound), car, plane, taxi, bus, or bus (Greyhound, Flixbus)

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There are 9 ways to get from Panama City Beach to Port Saint Lucie by bus (Greyhound), car, plane, taxi, bus, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee - FSU - Old St Augustine at Intramural Field to Kissimmee -1471 East Osceola Parkwaybus bus
    3. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    12h 17m
    $122–223

  2. Bus via Oak Ridge

    cheapest
    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Orlandobus bus
    3. Take the bus from Orlando to Port St Luciebus bus
    13h 23m
    $83–141

  3. Drive 459.9 mi

    1. Drive from Panama City Beach to Port Saint Luciecar car 459.9 mi
    8h 23m
    $84–122

  4. Fly Northwest Florida Beaches International Airport to Melbourne International Airport, taxi, bus

    1. Fly from Northwest Florida Beaches International Airport (ECP) to Melbourne International Airport (MLB)plane plane ECP - MLB
    2. Take the taxi from Melbourne International Airport (MLB) to Sebastiantaxi taxi
    3. Take the bus from Sebastian to Port St Luciebus bus
    8h 21m
    $215–577

  5. Fly Northwest Florida Beaches International Airport to President Donald J. Trump International Airport, bus

    1. Fly from Northwest Florida Beaches International Airport (ECP) to President Donald J. Trump International Airport (PBI)plane plane ECP - PBI
    2. Take the bus from WPB ITC at BAY D to GATLIN BLVD at I-95 P/R LOTbus bus
    9h 20m
    $153–550

  6. Drive to Destin–Fort Walton Beach Airport, fly to Miami International Airport, bus

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane plane VPS - MIA
    3. Take the bus from Sheridan Tri-Rail Station to Fort Piercebus bus
    7h 5m
    $104–412

  7. Bus to Tallahassee, fly to Miami International Airport, bus

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Fly from Tallahassee (TLH) to Miami International Airport (MIA)plane plane TLH - MIA
    3. Take the bus from Sheridan Tri-Rail Station to Fort Piercebus bus
    9h 12m
    $142–486

  8. Bus to Pensacola International Airport, fly to Miami International Airport, bus

    1. Take the bus from Panama City Beach Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Miami International Airport (MIA)plane plane PNS - MIA
    3. Take the bus from Sheridan Tri-Rail Station to Fort Piercebus bus
    9h 31m
    $112–405

  9. Drive to Destin–Fort Walton Beach Airport, fly to President Donald J. Trump International Airport, bus

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to President Donald J. Trump International Airport (PBI)plane plane VPS - PBI
    3. Take the bus from WPB ITC at BAY D to GATLIN BLVD at I-95 P/R LOTbus bus
    10h 6m
    $110–502

Northwest Florida Beaches International Airport (ECP) to Melbourne International Airport (MLB) flights

Calendar23Weekly Planes
Duration5h 23mAverage Duration
Ticket$73Cheapest Price
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Questions & Answers

Map of how to get from Panama City Beach to Port Saint Lucie.ExpandLaunch map view
  • Distance: 487.4 mi
  • Duration: 12h 17m

What companies run services between Panama City Beach, FL, USA and Port Saint Lucie, FL, USA?

You can take a vehicle from Panama City Beach to Fort Pierce via Panama City Beach Bus Station, Tallahassee, C.K. Steele Plaza Gate 1, Florida State University 1st Circle, Tallahassee - FSU - Old St Augustine at Intramural Field, and Kissimmee -1471 East Osceola Parkway in around 12h 17m.

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