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How to get fromPanama City Beach to Spartanburgby plane, bus (Greyhound, Flixbus), or car

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There are 5 ways to get from Panama City Beach to Spartanburg by plane, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Greenville–Spartanburg International Airport

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Greenville–Spartanburg International Airport (GSP)plane plane ECP - GSP
    4h 16m
    $189–614

  2. Drive 464.8 mi

    cheapest
    1. Drive from Panama City Beach to Spartanburgcar car 464.8 mi
    8h 29m
    $85–123

  3. Bus via Greenville

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Greenvillebus bus
    13h 46m
    $157–256

  4. Fly to Asheville Regional Airport, drive

    1. Fly from Northwest Florida Beaches International Airport (ECP) to Asheville Regional Airport (AVL)plane plane ECP - AVL
    2. Drive from Asheville-Airport-AVL to Spartanburgcar car
    4h 51m
    $118–409

  5. Bus

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Servicios Zapata - Spartanburgbus bus
    15h 36m
    $129–293

Northwest Florida Beaches International Airport (ECP) to Greenville–Spartanburg International Airport (GSP) flights

Calendar74Weekly Planes
Duration4h 25mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

Map of how to get from Panama City Beach to Spartanburg.ExpandLaunch map view
  • Distance: 414 mi
  • Duration: 4h 16m

What companies run services between Panama City Beach, FL, USA and Spartanburg, SC, USA?

Delta, Southwest Airlines, and two other airlines fly from Northwest Florida Beaches International Airport (ECP) to Greenville–Spartanburg International Airport (GSP) every 2 hours. Alternatively, you can take a vehicle from Panama City Beach to Spartanburg via Panama City Beach Bus Station, Tallahassee, Atlanta Bus Station, and Greenville in around 13h 46m.

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