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How to get fromPanama City Beach to St. Louisby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 7 ways to get from Panama City Beach to St. Louis by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Northwest Florida Beaches International Airport to Lambert–St. Louis International Airport

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Lambert–St. Louis International Airport (STL)plane plane ECP - STL
    2h 55m
    $157–617

  2. Drive to Destin–Fort Walton Beach Airport, fly to Midamerica St. Louis Airport

    cheapest
    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Midamerica St. Louis Airport (BLV)plane plane VPS - BLV
    4h 18m
    $102–408

  3. Bus

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus
    21h 19m
    $145–286

  4. Bus, train

    1. Take the bus from Panama City Beach Bus Station to Mobile Bus Stationbus bus
    2. Take the bus from Mobile Bus Station to New Orleans Bus Stationbus bus
    3. Take the train from New Orleans Union Passenger Terminal to Carbondaletrain train
    4. Take the bus from Carbondale to St. Louisbus bus
    25h 2m
    $270–576

  5. Drive 748 mi

    1. Drive from Panama City Beach to St. Louiscar car 748 mi
    13h 32m
    $137–198

  6. Drive to Destin–Fort Walton Beach Airport, fly to Lambert–St. Louis International Airport

    1. Drive from Panama City Beach to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL)plane plane VPS - STL
    3h 57m
    $114–569

  7. Bus #2

    1. Take the bus from Panama City Beach Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    21h 19m
    $145–286

Northwest Florida Beaches International Airport (ECP) to Lambert–St. Louis International Airport (STL) flights

Calendar29Weekly Planes
Duration2h 53mAverage Duration
Ticket$103Cheapest Price
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Questions & Answers

Map of how to get from Panama City Beach to St. Louis.ExpandLaunch map view
  • Distance: 667.2 mi
  • Duration: 2h 55m

What companies run services between Panama City Beach, FL, USA and St. Louis, MO, USA?

Southwest Airlines and Delta fly from Northwest Florida Beaches International Airport (ECP) to Lambert–St. Louis International Airport (STL) 4 times a day. Alternatively, you can take a vehicle from Panama City Beach to St Louis Bus Station via Panama City Beach Bus Station, Tallahassee, and Nashville Bus Station in around 21h 19m.

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