What is the cheapest way to get from Panama City to Florida Keys?

The cheapest way to get from Panama City to Florida Keys is to drive which costs $120 - $180 and takes 13h 28m.

What is the fastest way to get from Panama City to Florida Keys?

The fastest way to get from Panama City to Florida Keys is to fly which takes 7h 49m and costs $210 - $550.

How far is it from Panama City to Florida Keys?

The distance between Panama City and Florida Keys is 518 miles. The road distance is 687.9 miles.

How long does it take to get from Panama City to Florida Keys?

It takes approximately 7h 49m to get from Panama City to Florida Keys, including transfers.

Can I drive from Panama City to Florida Keys?

Yes, the driving distance between Panama City to Florida Keys is 688 miles. It takes approximately 13h 28m to drive from Panama City to Florida Keys.

Where can I stay near Florida Keys?

There are 866+ hotels available in Florida Keys.

Panama City to Florida Keys - 7 ways to travel via plane, car, bus, and shuttle

How to get fromPanama City to Florida Keys

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There are 7 ways to get from Panama City to Florida Keys by plane, car, bus, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly Northwest Florida Beaches International Airport to Key West International Airport
best
1. Fly from Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW)plane ECP - EYW
7h 49m
$212–521
Drive 683.9 mi
cheapest
1. Drive from Panama City to Florida Keyscar 683.9 mi
13h 28m
$125–181
Drive, bus
1. Drive from Front Beach Rd. & Back Beach Rd. to Crestviewcar
2. Take the bus from Crestview to Miamibus
3. Take the bus from Miami Airport Station to Big Pine Keybus
24h 36m
$158–230
Drive to Destin–Fort Walton Beach Airport, fly to Key West International Airport
1. Drive from Panama City to Destin–Fort Walton Beach Airport (VPS)car
2. Fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW)plane VPS - EYW
8h 38m
$144–422
Drive to Tallahassee, fly to Key West International Airport
1. Drive from Panama City to Tallahassee (TLH)car
2. Fly from Tallahassee (TLH) to Key West International Airport (EYW)plane TLH - EYW
8h 15m
$149–449
Drive to Tallahassee, fly to Miami International Airport, shuttle
1. Drive from Panama City to Tallahassee (TLH)car
2. Fly from Tallahassee (TLH) to Miami International Airport (MIA)plane TLH - MIA
3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle
8h 56m
$229–569
Drive to Destin–Fort Walton Beach Airport, fly to Miami International Airport, shuttle
1. Drive from Panama City to Destin–Fort Walton Beach Airport (VPS)car
2. Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane VPS - MIA
3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle
8h 50m
$224–542

Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW) flights

36Weekly Planes

6h 9mAverage Duration

$72Cheapest Price

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Questions & Answers

Map of how to get from Panama City to Florida Keys.

Launch map view

Distance: 515.1 mi
Duration: 7h 49m

What companies run services between Panama City, FL, USA and Florida Keys, FL, USA?

Delta and American Airlines fly from Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW) 5 times a day.

Airlines

Bus operators

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How to get fromPanama City to Florida Keysby plane, car, bus, or shuttle

There are 7 ways to get from Panama City to Florida Keys by plane, car, bus, or shuttle

Fly Northwest Florida Beaches International Airport to Key West International Airport

Drive 683.9 mi

Drive, bus

Drive to Destin–Fort Walton Beach Airport, fly to Key West International Airport

Drive to Tallahassee, fly to Key West International Airport

Drive to Tallahassee, fly to Miami International Airport, shuttle

Drive to Destin–Fort Walton Beach Airport, fly to Miami International Airport, shuttle