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How to get fromPanama City to Key Westby plane, car, bus, or ferry

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There are 8 ways to get from Panama City to Key West by plane, car, bus, or ferry

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Northwest Florida Beaches International Airport

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW)plane plane ECP - EYW
    5h 3m
    $146–440

  2. Drive to Destin–Fort Walton Beach Airport, fly

    cheapest
    1. Drive from Panama City to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW)plane plane VPS - EYW
    5h 51m
    $78–341

  3. Drive, bus, ferry

    1. Drive from Front Beach Rd. & Back Beach Rd. to Crestviewcar car
    2. Take the bus from Crestview to Fort Myersbus bus
    3. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    20h 11m
    $294–340

  4. Drive 699.3 mi

    1. Drive from Panama City to Key Westcar car 699.3 mi
    13h 51m
    $128–185

  5. Drive to Tallahassee, fly

    1. Drive from Panama City to Tallahassee (TLH)car car
    2. Fly from Tallahassee (TLH) to Key West International Airport (EYW)plane plane TLH - EYW
    5h 28m
    $83–368

  6. Drive to Dothan Regional Airport, fly

    1. Drive from Panama City to Dothan Regional Airport (DHN)car car
    2. Fly from Dothan Regional Airport (DHN) to Key West International Airport (EYW)plane plane DHN - EYW
    6h 37m
    $92–377

  7. Drive to Pensacola International Airport, fly

    1. Drive from Panama City to Pensacola-Airport-PNScar car
    2. Fly from Pensacola International Airport (PNS) to Key West International Airport (EYW)plane plane PNS - EYW
    6h 30m
    $300–741

  8. Drive, bus

    1. Drive from Front Beach Rd. & Back Beach Rd. to Crestviewcar car
    2. Take the bus from Crestview to Miamibus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    25h 23m
    $158–230

Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW) flights

Calendar36Weekly Planes
Duration6h 9mAverage Duration
Ticket$72Cheapest Price
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Questions & Answers

Map of how to get from Panama City to Key West.ExpandLaunch map view
  • Distance: 495.9 mi
  • Duration: 5h 3m

What companies run services between Panama City, FL, USA and Key West, FL, USA?

Delta and American Airlines fly from Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW) 5 times a day.

Airlines
Bus operators
Ferry operators

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