Rome2Rio

How to get fromPanama City to St. Louisby plane or car

Find Transport to St. Louis

See all options

There are 5 ways to get from Panama City to St. Louis by plane or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Northwest Florida Beaches International Airport to Lambert–St. Louis International Airport

    best
    1. Fly from Northwest Florida Beaches International Airport (ECP) to Lambert–St. Louis International Airport (STL)plane plane ECP - STL
    3h
    $168–630

  2. Drive to Pensacola International Airport, fly to Lambert–St. Louis International Airport

    cheapest
    1. Drive from Panama City to Pensacola-Airport-PNScar car
    2. Fly from Pensacola International Airport (PNS) to Lambert–St. Louis International Airport (STL)plane plane PNS - STL
    5h 2m
    $102–481

  3. Drive 743.7 mi

    1. Drive from Panama City to St. Louiscar car 743.7 mi
    13h 30m
    $136–196

  4. Drive to Destin–Fort Walton Beach Airport, fly to Lambert–St. Louis International Airport

    1. Drive from Panama City to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL)plane plane VPS - STL
    4h 10m
    $110–571

  5. Drive to Destin–Fort Walton Beach Airport, fly to Midamerica St. Louis Airport

    1. Drive from Panama City to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Midamerica St. Louis Airport (BLV)plane plane VPS - BLV
    4h 31m
    $103–410

Northwest Florida Beaches International Airport (ECP) to Lambert–St. Louis International Airport (STL) flights

Calendar29Weekly Planes
Duration2h 53mAverage Duration
Ticket$100Cheapest Price
See schedules

Questions & Answers

Map of how to get from Panama City to St. Louis.ExpandLaunch map view
  • Distance: 671.4 mi
  • Duration: 3h

What companies run services between Panama City, FL, USA and St. Louis, MO, USA?

Southwest Airlines and Delta fly from Northwest Florida Beaches International Airport (ECP) to Lambert–St. Louis International Airport (STL) 4 times a day.

Airlines

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides