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How to get fromPanama City to Cayo Santa Maríaby plane or bus

Find Transport to Cayo Santa María

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There are 2 ways to get from Panama City to Cayo Santa María by plane or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Tocumen International Airport to Abel Santamaría Airport, bus

    best
    1. Fly from Tocumen International Airport (PTY) to Abel Santamaría Airport (SNU)plane plane PTY - SNU
    2. Take the bus from Santa Clara to Cayo Santa Maríabus bus
    18h 58m
    $179–621

  2. Fly Panama Pacific International Airport to José Martí International Airport, bus

    1. Fly from Panama Pacific International Airport (BLB) to José Martí International Airport (HAV)plane plane BLB - HAV
    2. Take the bus from Havana Airport to Matanzasbus bus
    3. Take the bus from Matanzas to Santa Clarabus bus
    4. Take the bus from Santa Clara to Cayo Santa Maríabus bus
    12h 42m
    $258–488

Tocumen International Airport (PTY) to Abel Santamaría Airport (SNU) flights

Calendar22Weekly Planes
Duration18h 17mAverage Duration
Ticket$120Cheapest Price
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Questions & Answers

Map of how to get from Panama City to Cayo Santa María.ExpandLaunch map view
  • Distance: 1,647.1 km
  • Duration: 18h 58m

What companies run services between Panama City, Panama and Cayo Santa María, Villa Clara, Cuba?

There is no direct connection from Panama City to Cayo Santa María. However, you can take the shuttle to Aeropuerto Internacional de Tocumen, walk to Tocumen International Airport (PTY) airport, fly to Abel Santamaría Airport (SNU), take the taxi to Santa Clara, then take the bus to Cayo Santa María. Alternatively, you can take the taxi to Panama Pacific International Airport (BLB) airport, fly to José Martí International Airport (HAV), walk to Havana Airport, take the bus to Matanzas, take the bus to Santa Clara, take the bus to Vc, walk to Santa Clara, then take the bus to Cayo Santa María.

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