How to get fromPanama City to Guayaquilby plane, car, ferry, bus, or taxi

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There are 4 ways to get from Panama City to Guayaquil by plane, car, ferry, bus, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly from Tocumen International Airport
best
1. Fly from Tocumen International Airport (PTY) to José Joaquín De Olmedo International Airport (GYE)plane PTY - GYE
4h 38m
$238–478
Fly from Panama Pacific International Airport
cheapest
1. Fly from Panama Pacific International Airport (BLB) to José Joaquín De Olmedo International Airport (GYE)plane BLB - GYE
4h 41m
$197–770
Drive, ferry, bus, taxi
1. Drive from Panama City to Portobelocar
2. Take the ferry from Portobelo to Cartagenaferry
3. Take the bus from Terminal de Transporte de Cartagena to Terminal del Nortebus
4. Take the taxi from Medellín to Rumichacataxi
5. Take the bus from Rumichaca to Terminal Terrestre Quitumbebus
6. Take the bus from Terminal Terrestre Quitumbe to Guayaquilbus
7d 22h
$1,555–1,603
Drive, ferry, bus
1. Drive from Panama City to Puerto Lindocar
2. Take the ferry from Puerto Lindo to Cartagenaferry
3. Take the bus from Terminal de Transporte de Cartagena to Terminal Salitrebus
4. Take the bus from Terminal Salitre to Terminales de Transportes de Ipialesbus
5. Take the bus from Rumichaca to Terminal Terrestre Quitumbebus
6. Take the bus from Terminal Terrestre Quitumbe to Duránbus
8d 18h
$866–960

Tocumen International Airport (PTY) to José Joaquín De Olmedo International Airport (GYE) flights

60Weekly Planes

2h 43mAverage Duration

$67Cheapest Price

Questions & Answers

Map of how to get from Panama City to Guayaquil.

Launch map view

Distance: 1,272.7 km
Duration: 4h 38m

What companies run services between Panama City, Panama and Guayaquil, Ecuador?

Copa Airlines and Avianca - Aerovías del Continente Americano S.A. fly from Tocumen International Airport (PTY) to José Joaquín De Olmedo International Airport (GYE) every 3 hours.

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Guayaquil(opens in a new window), Ecuador(opens in a new window)

Guayaquil, officially Santiago de Guayaquil, is the largest city in Ecuador and also the nation's economic capital and main port. The city is the capital of Guayas Province and the seat of Guayaquil Canton. The city is located on the west bank of the Guayas River, which flows into the Pacific Ocean at the Gulf of Guayaquil. - Wikipedia (opens in a new window)

Places to stay in Guayaquil

Wyndham Guayaquil, Puerto Santa Ana(Opens in a new window)

9.2Superb

Oro Verde Guayaquil(Opens in a new window)

8.9Fabulous

Grand Hotel Guayaquil, Centro Histórico(Opens in a new window)

9.1Superb

Hotel Ramada(Opens in a new window)

8.0Good

Rome2Rio makes travelling from Panama City to Guayaquil easy.

Rome2Rio is a door-to-door travel information and booking engine, helping you get to and from any location in the world. Find all the transport options for your trip from Panama City to Guayaquil right here. Rome2Rio displays up to date schedules, route maps, journey times and estimated fares from relevant transport operators, ensuring you can make an informed decision about which option will suit you best. Rome2Rio also offers online bookings for selected operators, making reservations easy and straightforward.