There are 6 ways to get from Panama City to Mexicali by plane, bus, car, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to General Rodolfo Sánchez Taboada International Airport
best- Fly from Tocumen International Airport (PTY) to General Rodolfo Sánchez Taboada International Airport (MXL)plane PTY - MXL
12h 19m$5,650–19,500Fly to San Diego International Airport, bus
cheapest- Fly from Tocumen International Airport (PTY) to San Diego International Airport (SAN)plane PTY - SAN
- Take the bus from Tijuana to Mexicalibus
13h 48m$4,750–16,725Bus via Mexico City
- Take the bus from Terminal de Albrook to Terminal Tica Busbus
- Take the bus from Terminal Atlántico Norte to Terminal San Carlos - CCAbus
- Take the bus from San Salvador to Tapachulabus
- Take the bus from Tapachula to Politécnicobus
- Take the bus from Terminal Central de Autobuses del Norte to Mexicalibus
4d 12h$7,253–13,064Drive 5,765.3 km
- Drive from Panama City to Mexicalicar 5,765.3 km
3d$14,536–20,996Fly to Tijuana International Airport, bus
- Fly from Tocumen International Airport (PTY) to Tijuana International Airport (TIJ)plane PTY - TIJ
- Take the bus from Tijuana International Airport to Mexicalibus
14h 20m$4,850–17,350Bus
- Take the bus from Terminal de Albrook to Terminal Tica Busbus
- Take the bus from Terminal NicaBus to Managuabus
- Take the bus from Managua to Los Angelesbus
- Take the bus from Los Angeles Downtown to Calexico Bus Stationbus
5d 15h$8,394–10,815
Tocumen International Airport (PTY) to General Rodolfo Sánchez Taboada International Airport (MXL) flights
Comparing Your Travel Options
The cheapest way to get from Panama City to Mexicali is to bus which costs $8000 - $11000 and takes 5 days 15h.
The fastest way to get from Panama City to Mexicali is to fly which takes 12h 19m and costs $5500 - $20000.
No, there is no direct bus from Panama City to Mexicali. However, there are services departing from Terminal de Albrook and arriving at Mexicali via Terminal Atlántico Norte, San Salvador, Tapachula, Paradero Politécnico and Terminal Central de Autobuses del Norte. The journey, including transfers, takes approximately 4 days 12h.
The distance between Panama City and Mexicali is 4563 km. The road distance is 5765.3 km.
The best way to get from Panama City to Mexicali without a car is to bus which takes 5 days 15h and costs $8000 - $11000.
It takes approximately 12h 19m to get from Panama City to Mexicali, including transfers.
Panama City to Mexicali bus services, operated by Cristóbal Colón Autobuses (Línea Dorada y Trans Galgos Inter), depart from Terminal de Albrook station.
The best way to get from Panama City to Mexicali is to fly which takes 12h 19m and costs $5500 - $20000. Alternatively, you can bus via Mexico City, which costs $7000 - $14000 and takes 4 days 12h.
Panama City to Mexicali bus services, operated by Cristóbal Colón Autobuses (Línea Dorada y Trans Galgos Inter), arrive at Terminal Tica Bus station.
Mexicali is 2h behind Panama City. It is currently 5:02 PM in Panama City and 3:02 PM in Mexicali.
What companies run services between Panama City, Panama and Mexicali, Mexico?
Copa Airlines, Volaris, and two other airlines fly from Tocumen International Airport (PTY) to General Rodolfo Sánchez Taboada International Airport (MXL) 5 times a day. Alternatively, you can take a bus from Terminal de Albrook to Mexicali via Terminal Tica Bus, Terminal Atlántico Norte, Terminal San Carlos - CCA, San Salvador, Tapachula, Politécnico, Paradero Politécnico, Poniente 112, and Terminal Central de Autobuses del Norte in around 4d 12h.
- Website
- copaair.com
Flights from Tocumen International Airport to General Rodolfo Sánchez Taboada International Airport via Mexico City
- Ave. Duration
- 10h 31m
- When
- Every day
- Estimated price
- $4,300–18,000
Flights from Tocumen International Airport to General Rodolfo Sánchez Taboada International Airport via Guadalajara
- Ave. Duration
- 14h 37m
- When
- Monday, Tuesday, Wednesday, and Sunday
- Estimated price
- $4,400–18,000
Flights from Tocumen International Airport to Tijuana International Airport via Guadalajara
- Ave. Duration
- 10h 57m
- When
- Every day
- Estimated price
- $3,800–16,000
Flights from Tocumen International Airport to Tijuana International Airport via Cancun
- Ave. Duration
- 9h 3m
- When
- Every day
- Estimated price
- $5,500–16,000
Flights from Tocumen International Airport to Tijuana International Airport via Mexico City
- Ave. Duration
- 11h 27m
- When
- Every day
- Estimated price
- $3,800–16,000
Flights from Tocumen International Airport to San Diego International Airport
- Ave. Duration
- 6h 42m
- When
- Monday, Wednesday, Friday, and Sunday
- Estimated price
- $3,600–15,000
Flights from Tocumen International Airport to San Diego International Airport via Los Angeles
- Ave. Duration
- 10h 48m
- When
- Every day
- Estimated price
- $3,800–15,000
Flights from Tocumen International Airport to San Diego International Airport via Denver
- Ave. Duration
- 11h 31m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $4,200–17,000
Bus from Terminal de Albrook to Terminal Tica Bus
- Ave. Duration
- 15h 30m
- Frequency
- 4 times a day
- Estimated price
- $1,069–1,700
- Schedules at
- Cristóbal Colón Autobuses (Línea Dorada y Trans Galgos Inter)
- Road
- $1,100–1,700
Bus from Terminal Atlántico Norte to Terminal San Carlos - CCA
- Ave. Duration
- 23h
- Frequency
- 3 times a week
- Estimated price
- $1,200–1,800
- Schedules at
- Cristóbal Colón Autobuses (Línea Dorada y Trans Galgos Inter)
- Road
- $1,200–1,800
Bus from Terminal de Albrook to Terminal Tica Bus
- Ave. Duration
- 15h 30m
- Frequency
- 4 times a day
- Estimated price
- $1,069–1,700
- Schedules at
- Cristóbal Colón Autobuses (Línea Dorada y Trans Galgos Inter)
- Road
- $1,100–1,700
Want to know more about travelling around Mexico
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
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Booking & Getting There
Yes, the driving distance between Panama City to Mexicali is 5765 km. It takes approximately 3 days 0h to drive from Panama City to Mexicali.
There are 95+ hotels available in Mexicali.

