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How to get fromPanama City to Santa Anaby plane, bus, car, or train

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There are 7 ways to get from Panama City to Santa Ana by plane, bus, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to John Wayne Airport Orange County

    best
    1. Fly from Tocumen International Airport (PTY) to John Wayne Airport Orange County (SNA)plane plane PTY - SNA
    11h 9m
    $347–1,173

  2. Fly to Ontario International Airport, train

    cheapest
    1. Fly from Tocumen International Airport (PTY) to Ontario International Airport (ONT)plane plane PTY - ONT
    2. Take the train from San Bernardino Depot to Santa Anatrain train
    16h 28m
    $289–955

  3. Bus

    1. Take the bus from Terminal Albrook to Terminal Tica Busbus bus
    2. Take the bus from Terminal NicaBus to Managuabus bus
    3. Take the bus from Managua to Los Angelesbus bus
    4. Take the bus from Flower / Pico to Disneyland Employee's Entrancebus bus
    5d 10h
    $429–532

  4. Drive 3,768.1 mi

    1. Drive from Panama City to Santa Anacar car 3,768.1 mi
    3d 4h
    $830–1,199

  5. Fly to Los Angeles International Airport, train

    1. Fly from Tocumen International Airport (PTY) to Los Angeles International Airport (LAX)plane plane PTY - LAX
    2. Take the train from Los Angeles to Santa Anatrain train
    11h 51m
    $456–674

  6. Fly to San Diego International Airport, train

    1. Fly from Tocumen International Airport (PTY) to San Diego International Airport (SAN)plane plane PTY - SAN
    2. Take the train from San Diego to Santa Anatrain train
    12h 24m
    $310–1,053

  7. Fly to Tijuana International Airport, bus

    1. Fly from Tocumen International Airport (PTY) to Tijuana International Airport (TIJ)plane plane PTY - TIJ
    2. Take the bus from Tijuana Aeropuerto, B.C. to Santa Anabus bus
    14h 20m

Tocumen International Airport (PTY) to John Wayne Airport Orange County (SNA) flights

Calendar37Weekly Planes
Duration11h 18mAverage Duration
Ticket$287Cheapest Price
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Questions & Answers

Map of how to get from Panama City to Santa Ana.ExpandLaunch map view
  • Distance: 2,995.6 mi
  • Duration: 11h 9m

What companies run services between Panama City, Panama and Santa Ana, CA, USA?

Delta, Copa Airlines, and two other airlines fly from Tocumen International Airport (PTY) to John Wayne Airport Orange County (SNA) 5 times a day. Alternatively, you can take a bus from Terminal Albrook to Main-Civic Center via Terminal Tica Bus, Terminal NicaBus, Managua, Los Angeles, Olympic / Union, Pico / Figueroa, Flower / Pico, Disneyland Employee's Entrance, and Harbor-East Shuttle Area in around 5d 10h.

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