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How to get fromPanama City to Santa Cruz de la Sierraby plane, car, ferry, or bus

Find Transport to Santa Cruz de la Sierra

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There are 4 ways to get from Panama City to Santa Cruz de la Sierra by plane, car, ferry, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Tocumen International Airport

    best
    1. Fly from Tocumen International Airport (PTY) to Viru Viru International Airport (VVI)plane plane PTY - VVI
    7h 51m
    $429–739

  2. Fly from Panama Pacific International Airport

    cheapest
    1. Fly from Panama Pacific International Airport (BLB) to Viru Viru International Airport (VVI)plane plane BLB - VVI
    7h 16m
    $298–921

  3. Drive, ferry, bus via Lima

    1. Drive from Panama City to Portobelocar car
    2. Take the ferry from Portobelo to Cartagenaferry ferry
    3. Take the bus from Terminal de Transporte de Cartagena to Terminal Cúcutabus bus
    4. Take the bus from Cúcuta to Gran Terminal Terrestre Plaza Nortebus bus
    5. Take the bus from Lima - Terminal Arriola to La Pazbus bus
    6. Take the bus from La Paz to Santa Cruzbus bus
    10d 20h
    $1,097–1,684

  4. Drive, ferry, bus

    1. Drive from Panama City to Portobelocar car
    2. Take the ferry from Portobelo to Cartagenaferry ferry
    3. Take the bus from Terminal de Transporte de Cartagena to Terminal Cúcutabus bus
    4. Take the bus from Cúcuta to Gran Terminal Terrestre Plaza Nortebus bus
    5. Take the bus from Oltursa Lima Terminal to La Pazbus bus
    6. Take the bus from La Paz to Santa Cruzbus bus
    10d 20h
    $1,129–1,277

Tocumen International Airport (PTY) to Viru Viru International Airport (VVI) flights

Calendar25Weekly Planes
Duration6h 56mAverage Duration
Ticket$163Cheapest Price
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Questions & Answers

Map of how to get from Panama City to Santa Cruz de la Sierra.ExpandLaunch map view
  • Distance: 3,509.9 km
  • Duration: 7h 51m

What companies run services between Panama City, Panama and Santa Cruz de la Sierra, Bolivia?

Copa Airlines and Avianca - Aerovías del Continente Americano S.A. fly from Tocumen International Airport (PTY) to Viru Viru International Airport (VVI) 4 times a day.

Airlines
Bus operators
Ferry operators

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