There are 7 ways to get from Panama City to Santa Fe by bus, car, plane, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Gran Terminal Nacional de Transporte to Santiago de Veraguasbus Panamá
- Take the bus from Santiago to Santa Fébus
4h 49m$22–29Bus via Fernandez de Cordoba
cheapest- Take the bus from Gran Terminal Nacional de Transporte to Santiagobus David
- Take the bus from Santiago to Santa Fébus
4h 58m$12–21Drive 287 km
- Drive from Panama City to Santa Fecar 287 km
4h 42m$40–57Fly Albrook Airport to Lago Bay, taxi, bus
- Fly from Albrook Airport to Lago Bayplane
- Take the taxi from Lago Bay to Santiagotaxi
- Take the bus from Santiago to Santa Fébus
3h 31m$898–2,273Bus via Penonomé
- Take the bus from Gran Terminal Nacional de Transporte to Penonomébus
- Take the bus from Penonomé to Santiago de Veraguasbus
- Take the bus from Santiago to Santa Fébus
5h 24m$21–29Bus via La Chorrera
- Take the bus from La Chorrera to Santiagobus Panama City
- Take the bus from Santiago to Santa Fébus
7h 3m$14–16Fly Albrook Marcos A. Gelabert International Airport to Chitre, bus
- Fly from Albrook Marcos A. Gelabert International Airport (PAC) to Chitre (CTD)plane PAC - CTD
- Take the bus from Chitré to Ocubus
- Take the bus from Ocu to Santiagobus
- Take the bus from Santiago to Santa Fébus
5h 19m$149–156
Albrook Airport to Lago Bay flights
Questions & Answers
The cheapest way to get from Panama City to Santa Fe is to bus via Fernandez de Cordoba which costs $12 - $22 and takes 4h 58m.
The fastest way to get from Panama City to Santa Fe is to fly and taxi and bus which takes 3h 31m and costs $900 - $2,300.
No, there is no direct bus from Panama City to Santa Fe. However, there are services departing from Gran Terminal Nacional de Transporte and arriving at Santa Fé via Santiago. The journey, including transfers, takes approximately 4h 49m.
The distance between Panama City and Santa Fe is 310 km. The road distance is 287 km.
The best way to get from Panama City to Santa Fe without a car is to bus which takes 4h 49m and costs $21 - $29.
It takes approximately 4h 49m to get from Panama City to Santa Fe, including transfers.
Panama City to Santa Fe bus services, operated by Cristóbal Colón Autobuses (Línea Dorada y Trans Galgos Inter), depart from Gran Terminal Nacional de Transporte station.
Panama City to Santa Fe bus services, operated by Cristóbal Colón Autobuses (Línea Dorada y Trans Galgos Inter), arrive at Santiago de Veraguas station.
Yes, the driving distance between Panama City to Santa Fe is 287 km. It takes approximately 4h 42m to drive from Panama City to Santa Fe.
There are eight+ hotels available in Santa Fe.
What companies run services between Panama City, Panama and Santa Fe, Veraguas, Panama?
You can take a bus from Gran Terminal Nacional de Transporte to Santa Fé via Santiago de Veraguas and Santiago in around 4h 49m.
- Website
- airpanama.com
Flights from Albrook Marcos A. Gelabert International Airport to Chitre
- Ave. Duration
- 30 min
- When
- Tuesday to Friday
- Estimated price
- $29–230
Bus from Gran Terminal Nacional de Transporte to Santiago de Veraguas
- Ave. Duration
- 3h 30m
- Frequency
- Twice daily
- Estimated price
- $18–26
- Schedules at
- Cristóbal Colón Autobuses (Línea Dorada y Trans Galgos Inter)
- Road
- $18–26
Bus from Gran Terminal Nacional de Transporte to Penonomé
- Ave. Duration
- 2h 25m
- Frequency
- Twice daily
- Estimated price
- $11–16
- Schedules at
- Cristóbal Colón Autobuses (Línea Dorada y Trans Galgos Inter)
- Road
- $11–16
Bus from Penonomé to Santiago de Veraguas
- Ave. Duration
- 1h 5m
- Frequency
- Twice daily
- Estimated price
- $7–11
- Schedules at
- Cristóbal Colón Autobuses (Línea Dorada y Trans Galgos Inter)
- Road
- $7–11
Bus from Santiago to Santa Fé
- Ave. Duration
- 50 min
- Frequency
- Every 30 minutes
- Estimated price
- $3
Bus from Santiago to Santa Fé
- Ave. Duration
- 50 min
- Frequency
- Every 30 minutes
- Estimated price
- $3
Bus from Santiago to Santa Fé
- Ave. Duration
- 50 min
- Frequency
- Every 30 minutes
- Estimated price
- $3
Bus from Santiago to Santa Fé
- Ave. Duration
- 50 min
- Frequency
- Every 30 minutes
- Estimated price
- $3
Bus from Santiago to Santa Fé
- Ave. Duration
- 50 min
- Frequency
- Every 30 minutes
- Estimated price
- $3
Bus from Chitré to Ocu
- Ave. Duration
- 1h
- Frequency
- Every 30 minutes
- Estimated price
- $3
Bus from Ocu to Santiago
- Ave. Duration
- 1h
- Frequency
- Every 20 minutes
- Estimated price
- $2
Bus from Santiago to Santa Fé
- Ave. Duration
- 50 min
- Frequency
- Every 30 minutes
- Estimated price
- $3
Bus from Gran Terminal Nacional de Transporte to Santiago
- Ave. Duration
- 3h 42m
- Frequency
- Hourly
- Estimated price
- $18
Bus from Gran Terminal Nacional de Transporte to Santiago
- Ave. Duration
- 4h
- Frequency
- Every 2 hours
- Estimated price
- $14
- Schedules at
- Transporte Panama Chiriqui Frontera S.A (Panachif)
- Phone
- +507958-6484
- Website
- Expreso Veraguense
Bus from Gran Terminal Nacional de Transporte to Santiago
- Ave. Duration
- 4h 30m
- Frequency
- Every 3 hours
- Estimated price
- $9
- Schedules at
- Expreso Veraguense
Bus from La Chorrera to Santiago
- Ave. Duration
- 3h 54m
- Frequency
- Every 3 hours
- Estimated price
- $9
- Schedules at
- Expreso Veraguense
- Phone
- +507 314 6231
- Website
- Vepasa Sanpasa
Bus from Gran Terminal Nacional de Transporte to Santiago
- Ave. Duration
- 6h
- Frequency
- Every 5 minutes
- Estimated price
- $11
- Website
- Vepasa Sanpasa
- Phone
- +507 303-6466
Bus from Gran Terminal Nacional de Transporte to Penonomé
- Ave. Duration
- 2h
- Frequency
- Hourly
- Estimated price
- $6
- Ave. Duration
- 1h 41m
- Estimated price
- $55–70
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