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How to get fromPanama City to Santiago de Cubaby plane, shuttle, or bus

Find Transport to Santiago de Cuba

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There are 5 ways to get from Panama City to Santiago de Cuba by plane, shuttle, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Tocumen International Airport to Antonio Maceo International Airport

    best
    1. Fly from Tocumen International Airport (PTY) to Antonio Maceo International Airport (SCU)plane plane PTY - SCU
    9h 23m
    $131–511

  2. Fly Panama Pacific International Airport to Frank País International Airport, shuttle

    1. Fly from Panama Pacific International Airport (BLB) to Frank País International Airport (HOG)plane plane BLB - HOG
    2. Take a shuttle bus from Hotel Pernik Holguin to Melia Santiago de Cubashuttle bus
    21h 25m
    $210–538

  3. Fly Tocumen International Airport to Frank País International Airport, shuttle

    1. Fly from Tocumen International Airport (PTY) to Frank País International Airport (HOG)plane plane PTY - HOG
    2. Take a shuttle bus from Hotel Pernik Holguin to Melia Santiago de Cubashuttle bus
    18h 57m
    $191–676

  4. Fly Tocumen International Airport to Ignacio Agramonte International Airport, bus

    1. Fly from Tocumen International Airport (PTY) to Ignacio Agramonte International Airport (CMW)plane plane PTY - CMW
    2. Take the bus from Camagüey to Santiago de Cubabus bus
    20h 48m
    $162–595

  5. Fly Panama Pacific International Airport to Antonio Maceo International Airport

    1. Fly from Panama Pacific International Airport (BLB) to Antonio Maceo International Airport (SCU)plane plane BLB - SCU
    5h 48m
    $210–523

Tocumen International Airport (PTY) to Antonio Maceo International Airport (SCU) flights

Calendar9Weekly Planes
Duration9h 36mAverage Duration
Ticket$92Cheapest Price
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Questions & Answers

Map of how to get from Panama City to Santiago de Cuba.ExpandLaunch map view
  • Distance: 1,301.4 km
  • Duration: 9h 23m

What companies run services between Panama City, Panama and Santiago de Cuba?

Copa Airlines, Euroairlines, and three other airlines fly from Tocumen International Airport (PTY) to Antonio Maceo International Airport (SCU) once daily.

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