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How to get fromPanama to Santiago de Cubaby plane, shuttle, or bus

Find Transport to Santiago de Cuba

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There are 4 ways to get from Panama to Santiago de Cuba by plane, shuttle, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly David to Antonio Maceo International Airport

    best
    1. Fly from David (DAV) to Antonio Maceo International Airport (SCU)plane plane DAV - SCU
    9h 49m
    $216–1,007

  2. Fly Tocumen International Airport to Antonio Maceo International Airport

    cheapest
    1. Fly from Tocumen International Airport (PTY) to Antonio Maceo International Airport (SCU)plane plane PTY - SCU
    9h 29m
    $138–523

  3. Fly Tocumen International Airport to Frank País International Airport, shuttle

    1. Fly from Tocumen International Airport (PTY) to Frank País International Airport (HOG)plane plane PTY - HOG
    2. Take a shuttle bus from Hotel Pernik Holguin to Melia Santiago de Cubashuttle bus
    19h 3m
    $193–678

  4. Fly Tocumen International Airport to Ignacio Agramonte International Airport, bus

    1. Fly from Tocumen International Airport (PTY) to Ignacio Agramonte International Airport (CMW)plane plane PTY - CMW
    2. Take the bus from Camagüey to Santiago de Cubabus bus
    20h 54m
    $164–597

David (DAV) to Antonio Maceo International Airport (SCU) flights

Calendar5Weekly Planes
Duration13h 38mAverage Duration
Ticket$212Cheapest Price
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Questions & Answers

Map of how to get from Panama to Santiago de Cuba.ExpandLaunch map view
  • Distance: 1,480.9 km
  • Duration: 9h 49m

What companies run services between Panama and Santiago de Cuba?

Copa Airlines, InterCaribbean Airways, and three other airlines fly from David (DAV) to Antonio Maceo International Airport (SCU) 5 times a week.

Airlines
Bus operators

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