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How to get fromPenn Station NY to St. Louisby plane, bus (Greyhound), train (Amtrak), car, train, or bus (Flixbus, Greyhound)

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There are 9 ways to get from Penn Station NY to St. Louis by plane, bus (Greyhound), train (Amtrak), car, train, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Newark Liberty International Airport

    best
    1. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)plane plane EWR - STL
    5h 1m
    $393–830

  2. Fly from John F. Kennedy International Airport

    cheapest
    1. Fly from John F. Kennedy International Airport (JFK) to Lambert–St. Louis International Airport (STL)plane plane JFK - STL
    5h 21m
    $137–621

  3. Bus (Greyhound)

    1. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus Greyhound US0421
    23h 12m
    $160–310

  4. Train (Amtrak)

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Chicago Union Stationtrain train Lake Shore Limited / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    25h 25m
    $401–822

  5. Drive 944.6 mi

    1. Drive from Penn Station NY to St. Louiscar car 944.6 mi
    16h 29m
    $173–249

  6. Fly from Laguardia Airport

    1. Fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL)plane plane LGA - STL
    5h 13m
    $151–459

  7. Train to Philadelphia International Airport, fly

    1. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    6h 6m
    $177–1,402

  8. Train to Long Island Mac Arthur Airport, fly

    1. Take the train from New York Penn Station to Central Isliptrain train
    2. Fly from Long Island Mac Arthur Airport (ISP) to Lambert–St. Louis International Airport (STL)plane plane ISP - STL
    8h 37m
    $159–733

  9. Bus via Newark, Penn Station

    1. Take the bus from New York Midtown to Newark Penn Stationbus bus FlixBus N2605 / ...
    2. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus Greyhound US0421
    24h 7m
    $160–306

Penn Station NY to St. Louis by foot and bus (Greyhound)

Calendar21Weekly Services
Duration23h 12mAverage Duration
Ticket$160Cheapest Price
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Questions & Answers

Map of how to get from Penn Station NY to St. Louis.ExpandLaunch map view
  • Distance: 898 mi
  • Duration: 5h 1m

What companies run services between Penn Station NY, USA and St. Louis, MO, USA?

United Airlines, Delta, and Air Canada fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, Greyhound USA operates a bus from Port Authority Bus Terminal to St Louis Bus Station 3 times a day. Tickets cost $160–310 and the journey takes 23h.

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