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How to get fromPennsylvania to Louisvilleby plane, bus (Greyhound, Amtrak), train, bus, car, or bus (Flixbus, Amtrak)

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There are 8 ways to get from Pennsylvania to Louisville by plane, bus (Greyhound, Amtrak), train, bus, car, or bus (Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Philadelphia International Airport to Louisville International Airport

    best
    1. Fly from Philadelphia International Airport (PHL) to Louisville International Airport (SDF)plane plane PHL - SDF
    4h 45m
    $144–857

  2. Fly Philadelphia International Airport to Blue Grass Airport, drive

    cheapest
    1. Fly from Philadelphia International Airport (PHL) to Blue Grass Airport (LEX)plane plane PHL - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    4h 40m
    $91–483

  3. Bus

    1. Take the bus from Philadelphia Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    17h 40m
    $140–218

  4. Train, bus (Amtrak)

    1. Take the train from 30th Street Station to Indianapolistrain train Cardinal
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    25h 37m
    $495–799

  5. Drive  668.3 mi

    1. Drive from Philadelphia to Louisvillecar car 668.3 mi
    11h 27m
    $122–177

  6. Train to Baltimore-Washington International Airport, fly to Louisville International Airport

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Louisville International Airport (SDF)plane plane BWI - SDF
    5h 57m
    $148–1,407

  7. Bus to Pittsburgh International Airport, fly to Louisville International Airport

    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Louisville International Airport (SDF)plane plane PIT - SDF
    4h 47m

  8. Bus via Reading

    1. Take the bus from Philadelphia Bus Station to Cincinnatibus bus
    2. Take the bus from Cincinnati to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    21h 30m
    $133–269

Pennsylvania to Louisville by bus

Calendar14Weekly Buses
Duration17h 40mAverage Duration
Ticket$140Cheapest Price
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Comparing Your Travel Options

Map of how to get from Pennsylvania to Louisville.ExpandLaunch map view
  • Distance: 589.7 mi
  • Duration: 4h 45m

What companies run services between Pennsylvania, USA and Louisville, KY, USA?

American Airlines, United Airlines, and two other airlines fly from Philadelphia International Airport (PHL) to Louisville International Airport (SDF) every 4 hours. Alternatively, you can take a bus from Philadelphia Bus Station to Louisville, KY via Indianapolis Union Station in around 17h 40m.

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