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How to get fromPennsylvania to Mayo Clinicby plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Greyhound)

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There are 12 ways to get from Pennsylvania to Mayo Clinic by plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Philadelphia International Airport to Rochester

    best
    1. Fly from Philadelphia International Airport (PHL) to Rochester (RST)plane plane PHL - RST
    7h 15m
    $134–693

  2. Fly Erie International Airport to Rochester

    cheapest
    1. Fly from Erie International Airport (ERI) to Rochester (RST)plane plane ERI - RST
    8h 37m
    $73–422

  3. Bus

    1. Take the bus from Philadelphia Bus Station to Newark Penn Stationbus bus
    2. Take the bus from Newark Penn Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    28h 38m
    $225–379

  4. Train, bus via Milwaukee

    1. Take the train from 30th Street Station to Washington Union Stationtrain train
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Milwaukeetrain train
    4. Take the bus from Milwaukee to Rochesterbus bus
    30h 37m
    $372–1,316

  5. Drive 1,104.7 mi

    1. Drive from Philadelphia to Mayo Cliniccar car 1,104.7 mi
    18h 10m
    $202–292

  6. Fly Pittsburgh International Airport to Rochester

    1. Fly from Pittsburgh International Airport (PIT) to Rochester (RST)plane plane PIT - RST
    7h 41m
    $86–477

  7. Fly Lehigh Valley International Airport to Rochester

    1. Fly from Lehigh Valley International Airport (ABE) to Rochester (RST)plane plane ABE - RST
    7h 37m
    $93–472

  8. Fly Philadelphia International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Philadelphia International Airport (PHL) to Minneapolis–Saint Paul International Airport (MSP)plane plane PHL - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 59m
    $235–905

  9. Fly Pittsburgh International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Pittsburgh International Airport (PIT) to Minneapolis–Saint Paul International Airport (MSP)plane plane PIT - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 15m
    $552–1,021

  10. Train, bus

    1. Take the train from 30th Street Station to Washington Union Stationtrain train
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochester, MNbus bus
    32h 29m
    $433–1,466

  11. Bus via Baltimore

    1. Take the bus from Philadelphia Bus Station to Baltimore Greyhound Garagebus bus
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    34h 53m
    $212–401

  12. Train, bus #2

    1. Take the train from 30th Street Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    38h 20m
    $418–833

Pennsylvania to Mayo Clinic by subway, train, bus, and foot

Calendar7Weekly Services
Duration32h 29mAverage Duration
Ticket$433Cheapest Price
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Questions & Answers

Map of how to get from Pennsylvania to Mayo Clinic.ExpandLaunch map view
  • Distance: 945.7 mi
  • Duration: 7h 15m

What companies run services between Pennsylvania, USA and Mayo Clinic, MN, USA?

Delta, United Airlines, and American Airlines fly from Philadelphia International Airport (PHL) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Philadelphia Bus Station to Mayo Clinic via Newark Penn Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 28h 38m.

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