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How to get fromPennsylvania to St. Louisby plane, bus (Greyhound), car, bus, or train

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There are 6 ways to get from Pennsylvania to St. Louis by plane, bus (Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Philadelphia International Airport

    best
    1. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    4h 24m
    $126–756

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Philadelphia Bus Station to St Louis Bus Stationbus bus Greyhound US0421
    20h 50m
    $120–250

  3. Drive 881.7 mi

    1. Drive from Philadelphia to St. Louiscar car 881.7 mi
    15h 1m
    $161–233

  4. Bus to Pittsburgh International Airport, fly

    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL)plane plane PIT - STL
    4h 35m

  5. Bus to Cleveland-Hopkins International Airport, fly

    1. Take the bus from Erie to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    5h 32m
    $512–936

  6. Train to Baltimore-Washington International Airport, fly

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Lambert–St. Louis International Airport (STL)plane plane BWI - STL
    5h 54m
    $150–1,306

Pennsylvania to St. Louis by bus (Greyhound)

Calendar21Weekly Buses
Duration20h 50mAverage Duration
Ticket$120Cheapest Price
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Questions & Answers

Map of how to get from Pennsylvania to St. Louis.ExpandLaunch map view
  • Distance: 833.7 mi
  • Duration: 4h 24m

What companies run services between Pennsylvania, USA and St. Louis, MO, USA?

American Airlines, Southwest Airlines, and Delta fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, Greyhound USA operates a bus from Philadelphia Bus Station to St Louis Bus Station 3 times a day. Tickets cost $120–250 and the journey takes 20h 50m.

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