Rome2Rio

How to get fromPennsylvania to St. Louisby bus, plane, bus (Greyhound), car, or train

Find Transport to St. Louis

See all options

There are 6 ways to get from Pennsylvania to St. Louis by bus, plane, bus (Greyhound), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Pittsburgh International Airport, fly

    best
    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL)plane plane PIT - STL
    4h 35m

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Philadelphia Bus Station to St Louis Bus Stationbus bus Greyhound US0421
    20h 50m
    $140–270

  3. Drive 881.7 mi

    1. Drive from Philadelphia to St. Louiscar car 881.7 mi
    15h 1m
    $161–233

  4. Fly from Philadelphia International Airport

    1. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    4h 24m
    $166–1,106

  5. Bus to Cleveland-Hopkins International Airport, fly

    1. Take the bus from Erie to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    5h 32m
    $514–939

  6. Train to Baltimore-Washington International Airport, fly

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Lambert–St. Louis International Airport (STL)plane plane BWI - STL
    5h 54m
    $160–1,356

Pennsylvania to St. Louis by bus (Greyhound)

Calendar21Weekly Buses
Duration20h 50mAverage Duration
Ticket$140Cheapest Price
See schedules

Questions & Answers

Map of how to get from Pennsylvania to St. Louis.ExpandLaunch map view
  • Distance: 590.5 mi
  • Duration: 4h 35m

What companies run services between Pennsylvania, USA and St. Louis, MO, USA?

Greyhound USA operates a bus from Philadelphia Bus Station to St Louis Bus Station 3 times a day. Tickets cost $140–270 and the journey takes 20h 50m. Alternatively, American Airlines, Southwest Airlines, and Delta fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL) every 4 hours.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers