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How to get fromPensacola to Des Moinesby car, plane, taxi, bus, train, bus (Greyhound, Flixbus, Amtrak), or bus (Greyhound)

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There are 9 ways to get from Pensacola to Des Moines by car, plane, taxi, bus, train, bus (Greyhound, Flixbus, Amtrak), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mobile Regional Airport, fly

    best
    1. Drive from Pensacola to Mobile-Airport-MOBcar car
    2. Fly from Mobile Regional Airport (MOB) to Des Moines (DSM)plane plane MOB - DSM
    6h 17m
    $190–789

  2. Fly from Pensacola International Airport

    cheapest
    1. Fly from Pensacola International Airport (PNS) to Des Moines (DSM)plane plane PNS - DSM
    7h 14m
    $161–675

  3. Taxi, bus, train

    1. Take the taxi from Pensacola to Mobiletaxi taxi
    2. Take the bus from Mobile to Gulfportbus bus
    3. Take the train from Gulfport, MS to New Orleans, LA - Union Passenger Terminaltrain train
    4. Take the train from New Orleans Union Passenger Terminal to Champaign-Urbanatrain train
    5. Take the bus from Champaign Intermodal Trans Ctr to Des Moinesbus bus
    31h 15m
    $488–897

  4. Bus via Nashville

    1. Take the bus from Pensacola to Tallahasseebus bus
    2. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    4. Take the bus from Carbondale to St. Louisbus bus
    5. Take the bus from St Louis Bus Station to Des Moinesbus bus
    32h 2m
    $245–460

  5. Drive 1,014.3 mi

    1. Drive from Pensacola to Des Moinescar car 1,014.3 mi
    19h 7m
    $186–268

  6. Drive to Northwest Florida Beaches International Airport, fly

    1. Drive from Pensacola to Northwest Florida Beaches International Airport (ECP)car car
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Des Moines (DSM)plane plane ECP - DSM
    7h 11m
    $185–797

  7. Bus to Destin–Fort Walton Beach Airport, fly

    1. Take the bus from Pensacola to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM)plane plane VPS - DSM
    7h 8m
    $259–889

  8. Taxi, bus, train via Pascagoula

    1. Take the taxi from Pensacola to Mobiletaxi taxi
    2. Take the bus from Mobile to Pascagoulabus bus
    3. Take the train from Pascagoula, MS to New Orleans, LA - Union Passenger Terminaltrain train
    4. Take the train from New Orleans Union Passenger Terminal to Champaign-Urbanatrain train
    5. Take the bus from Champaign to Des Moinesbus bus
    33h 56m

  9. Bus

    1. Take the bus from Pensacola to Tallahasseebus bus
    2. Take the bus from Tallahassee to Montgomery Intermodal Centerbus bus
    3. Take the bus from Montgomery Intermodal Center to Indianapolis Union Stationbus bus
    4. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    34h 47m
    $255–465

Mobile Regional Airport (MOB) to Des Moines (DSM) flights

Calendar66Weekly Planes
Duration6h 9mAverage Duration
Ticket$163Cheapest Price
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Questions & Answers

Map of how to get from Pensacola to Des Moines.ExpandLaunch map view
  • Distance: 883.3 mi
  • Duration: 6h 17m

What companies run services between Pensacola, FL, USA and Des Moines, IA, USA?

You can take a bus from Pensacola to Des Moines via Tallahassee, N Monroe Street and Silver Slipper Lane, Tallahassee, Nashville Bus Station, Carbondale, St. Louis, and St Louis Bus Station in around 32h 2m. Alternatively, Delta, American Airlines, and United Airlines fly from Pensacola International Airport (PNS) to Des Moines (DSM) every 3 hours.

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