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How to get fromPensacola to Des Moinesby bus, plane, taxi, train, bus (Greyhound), car, or bus (Flixbus, Greyhound)

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There are 8 ways to get from Pensacola to Des Moines by bus, plane, taxi, train, bus (Greyhound), car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Destin–Fort Walton Beach Airport, fly

    best
    1. Take the bus from Pensacola to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM)plane plane VPS - DSM
    4h 53m
    $190–571

  2. Fly from Pensacola International Airport

    cheapest
    1. Fly from Pensacola International Airport (PNS) to Des Moines (DSM)plane plane PNS - DSM
    6h 55m
    $107–447

  3. Taxi, bus, train

    1. Take the taxi from Pensacola to Mobiletaxi taxi
    2. Take the bus from Mobile to Gulfportbus bus
    3. Take the train from Gulfport, MS to New Orleans, LA - Union Passenger Terminaltrain train
    4. Take the train from New Orleans Union Passenger Terminal to Champaign-Urbanatrain train
    5. Take the bus from Champaign Intermodal Trans Ctr to Des Moinesbus bus
    31h 10m
    $692–1,042

  4. Bus

    1. Take the bus from Pensacola to Tallahasseebus bus
    2. Take the bus from Tallahassee to Montgomery Intermodal Centerbus bus
    3. Take the bus from Montgomery Intermodal Center to Indianapolis Union Stationbus bus
    4. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    34h 32m
    $275–410

  5. Drive  1,014.3 mi

    1. Drive from Pensacola to Des Moinescar car 1,014.3 mi
    19h 7m
    $186–268

  6. Drive to Mobile Regional Airport, fly

    1. Drive from Pensacola to Mobile Regional Airport (MOB)car car
    2. Fly from Mobile Regional Airport (MOB) to Des Moines (DSM)plane plane MOB - DSM
    6h 16m
    $121–501

  7. Drive to Northwest Florida Beaches International Airport, fly

    1. Drive from Pensacola to Northwest Florida Beaches International Airport (ECP)car car
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Des Moines (DSM)plane plane ECP - DSM
    7h 5m
    $126–499

  8. Bus via Atlanta

    1. Take the bus from Pensacola to Tallahasseebus bus
    2. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Bloomingtonbus bus
    4. Take the bus from Bloomington, IN to Indianapolis Union Stationbus bus
    5. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    35h 2m
    $279–445

Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM) flights

Calendar34Weekly Planes
Duration4h 43mAverage Duration
Ticket$83Cheapest Price
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Comparing Your Travel Options

Map of how to get from Pensacola to Des Moines.ExpandLaunch map view
  • Distance: 938.3 mi
  • Duration: 4h 53m

What companies run services between Pensacola, FL, USA and Des Moines, IA, USA?

You can take a bus from Pensacola to Des Moines via Tallahassee, N Monroe Street and Silver Slipper Lane, Tallahassee, Montgomery Intermodal Center, and Indianapolis Union Station in around 34h 32m. Alternatively, Delta, United Airlines, and two other airlines fly from Pensacola International Airport (PNS) to Des Moines (DSM) every 2 hours.

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