Rome2Rio

How to get fromPensacola to Des Moinesby car, plane, taxi, bus, train, bus (Greyhound), or bus (Flixbus, Greyhound)

Find Transport to Des Moines

See all options

There are 8 ways to get from Pensacola to Des Moines by car, plane, taxi, bus, train, bus (Greyhound), or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mobile Regional Airport, fly

    best
    1. Drive from Pensacola to Mobile Regional Airport (MOB)car car
    2. Fly from Mobile Regional Airport (MOB) to Des Moines (DSM)plane plane MOB - DSM
    6h 29m
    $121–511

  2. Fly from Pensacola International Airport

    cheapest
    1. Fly from Pensacola International Airport (PNS) to Des Moines (DSM)plane plane PNS - DSM
    7h 15m
    $102–447

  3. Taxi, bus, train

    1. Take the taxi from Pensacola to Mobiletaxi taxi
    2. Take the bus from Mobile to Gulfportbus bus
    3. Take the train from Gulfport, MS to New Orleans, LA - Union Passenger Terminaltrain train
    4. Take the train from New Orleans Union Passenger Terminal to Champaign-Urbanatrain train
    5. Take the bus from Champaign Intermodal Trans Ctr to Des Moinesbus bus
    31h 10m
    $413–787

  4. Bus

    1. Take the bus from Pensacola to Tallahasseebus bus
    2. Take the bus from Tallahassee to Montgomery Intermodal Centerbus bus
    3. Take the bus from Montgomery Intermodal Center to Indianapolis Union Stationbus bus
    4. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    34h 32m
    $255–395

  5. Drive  1,014.3 mi

    1. Drive from Pensacola to Des Moinescar car 1,014.3 mi
    19h 7m
    $186–268

  6. Drive to Northwest Florida Beaches International Airport, fly

    1. Drive from Pensacola to Northwest Florida Beaches International Airport (ECP)car car
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Des Moines (DSM)plane plane ECP - DSM
    7h 41m
    $126–509

  7. Bus to Destin–Fort Walton Beach Airport, fly

    1. Take the bus from Pensacola to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM)plane plane VPS - DSM
    7h 38m
    $200–601

  8. Bus via Atlanta

    1. Take the bus from Pensacola to Tallahasseebus bus
    2. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Bloomingtonbus bus
    4. Take the bus from Bloomington, IN to Indianapolis Union Stationbus bus
    5. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    35h 2m
    $264–440

Mobile Regional Airport (MOB) to Des Moines (DSM) flights

Calendar69Weekly Planes
Duration6h 44mAverage Duration
Ticket$94Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Pensacola to Des Moines.ExpandLaunch map view
  • Distance: 883.3 mi
  • Duration: 6h 29m

What companies run services between Pensacola, FL, USA and Des Moines, IA, USA?

You can take a bus from Pensacola to Des Moines via Tallahassee, N Monroe Street and Silver Slipper Lane, Tallahassee, Montgomery Intermodal Center, and Indianapolis Union Station in around 34h 32m. Alternatively, Delta, American Airlines, and United Airlines fly from Pensacola International Airport (PNS) to Des Moines (DSM) every 3 hours.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There