Rome2Rio

How to get fromPensacola to Knoxvilleby car, plane, bus (Greyhound, Flixbus), bus, bus (Flixbus, Greyhound), or train

Find Transport to Knoxville

See all options

There are 8 ways to get from Pensacola to Knoxville by car, plane, bus (Greyhound, Flixbus), bus, bus (Flixbus, Greyhound), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mobile Regional Airport, fly

    best
    1. Drive from Pensacola to Mobile-Airport-MOBcar car
    2. Fly from Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS)plane plane MOB - TYS
    4h 58m
    $168–688

  2. Drive 502.2 mi

    cheapest
    1. Drive from Pensacola to Knoxvillecar car 502.2 mi
    8h 29m
    $92–133

  3. Bus via Jacksonville

    1. Take the bus from Pensacola to Tallahasseebus bus
    2. Take the bus from Tallahassee to Jacksonvillebus bus
    3. Take the bus from Jacksonville to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 47m
    $380–565

  4. Bus to Destin–Fort Walton Beach Airport, fly

    1. Take the bus from Pensacola to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS)plane plane VPS - TYS
    3h 53m
    $242–788

  5. Fly from Pensacola International Airport

    1. Fly from Pensacola International Airport (PNS) to Mcghee Tyson Airport (TYS)plane plane PNS - TYS
    5h 47m
    $144–574

  6. Bus

    1. Take the bus from Pensacola to Tallahasseebus bus
    2. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to New York Midtownbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    42h 43m
    $433–663

  7. Bus #2

    1. Take the bus from Pensacola to Tallahasseebus bus
    2. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    44h 34m
    $423–693

  8. Bus, train

    1. Take the bus from Pensacola to Wildwoodbus bus
    2. Take the bus from Wildwood Amtrak Station to Jacksonvillebus bus
    3. Take the train from Jacksonville to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    44h 56m
    $620–1,070

Mobile Regional Airport (MOB) to Mcghee Tyson Airport (TYS) flights

Calendar76Weekly Planes
Duration5h 1mAverage Duration
Ticket$103Cheapest Price
See schedules

Questions & Answers

Map of how to get from Pensacola to Knoxville.ExpandLaunch map view
  • Distance: 512.8 mi
  • Duration: 4h 58m

What companies run services between Pensacola, FL, USA and Knoxville, TN, USA?

You can take a bus from Pensacola to Knoxville via Tallahassee, N Monroe Street and Silver Slipper Lane, Tallahassee, Jacksonville, New York, NY, and Knoxville, TN in around 40h 47m. Alternatively, Southwest Airlines, Delta, and American Airlines fly from Pensacola International Airport (PNS) to Mcghee Tyson Airport (TYS) every 4 hours.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers