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How to get fromPensacola to Saint Charlesby plane, bus (Greyhound, Flixbus), taxi, bus, train, car, or bus (Flixbus, Greyhound)

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There are 8 ways to get from Pensacola to Saint Charles by plane, bus (Greyhound, Flixbus), taxi, bus, train, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Pensacola International Airport to Lambert–St. Louis International Airport

    best
    1. Fly from Pensacola International Airport (PNS) to Lambert–St. Louis International Airport (STL)plane plane PNS - STL
    5h 12m
    $93–478

  2. Bus

    1. Take the bus from Pensacola to Tallahasseebus bus
    2. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus
    23h 47m
    $184–324

  3. Taxi, bus, train

    1. Take the taxi from Pensacola to Mobiletaxi taxi
    2. Take the bus from Mobile to Pascagoulabus bus
    3. Take the train from Pascagoula, MS to New Orleans, LA - Union Passenger Terminaltrain train
    4. Take the train from New Orleans Union Passenger Terminal to Carbondaletrain train
    5. Take the bus from Carbondale to St. Louisbus bus
    24h 14m
    $401–726

  4. Drive 711.6 mi

    1. Drive from Pensacola to Saint Charlescar car 711.6 mi
    13h 2m
    $130–188

  5. Drive to Northwest Florida Beaches International Airport, fly to Lambert–St. Louis International Airport

    1. Drive from Pensacola to Northwest Florida Beaches International Airport (ECP)car car
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Lambert–St. Louis International Airport (STL)plane plane ECP - STL
    5h 12m
    $122–580

  6. Bus to Destin–Fort Walton Beach Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Pensacola to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL)plane plane VPS - STL
    5h 11m
    $196–672

  7. Bus to Destin–Fort Walton Beach Airport, fly to Midamerica St. Louis Airport, train

    1. Take the bus from Pensacola to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Midamerica St. Louis Airport (BLV)plane plane VPS - BLV
    3. Take the train from SHILOH-SCOTT station to NORTH HANLEY stationtrain train
    6h 22m
    $184–511

  8. Bus #2

    1. Take the bus from Pensacola to Tallahasseebus bus
    2. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    23h 47m
    $184–324

Pensacola International Airport (PNS) to Lambert–St. Louis International Airport (STL) flights

Calendar26Weekly Planes
Duration2h 56mAverage Duration
Ticket$88Cheapest Price
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Questions & Answers

Map of how to get from Pensacola to Saint Charles.ExpandLaunch map view
  • Distance: 617.9 mi
  • Duration: 5h 12m

What companies run services between Pensacola, FL, USA and Saint Charles, MO, USA?

Southwest Airlines and Delta fly from Pensacola International Airport (PNS) to Lambert–St. Louis International Airport (STL) 4 times a day. Alternatively, you can take a bus from Pensacola to 4375 Rider Trail North Sb via Tallahassee, N Monroe Street and Silver Slipper Lane, Tallahassee, Nashville Bus Station, St Louis Bus Station, CIVIC CENTER station, NORTH HANLEY station, and North Hanley Transit Center in around 23h 47m.

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