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How to get fromPensacola to St. Louisby plane, taxi, bus, train, bus (Greyhound, Flixbus), car, or bus (Greyhound, Flixbus, Amtrak)

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There are 9 ways to get from Pensacola to St. Louis by plane, taxi, bus, train, bus (Greyhound, Flixbus), car, or bus (Greyhound, Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Pensacola International Airport to Lambert–St. Louis International Airport

    best
    1. Fly from Pensacola International Airport (PNS) to Lambert–St. Louis International Airport (STL)plane plane PNS - STL
    4h 48m
    $92–497

  2. Taxi, bus, train

    1. Take the taxi from Pensacola to Mobiletaxi taxi
    2. Take the bus from Mobile to Gulfportbus bus
    3. Take the train from Gulfport, MS to New Orleans, LA - Union Passenger Terminaltrain train
    4. Take the train from New Orleans Union Passenger Terminal to Carbondaletrain train
    5. Take the bus from Carbondale to St. Louisbus bus
    22h 18m
    $547–825

  3. Bus

    1. Take the bus from Pensacola to Tallahasseebus bus
    2. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus
    22h 27m
    $200–305

  4. Drive  699.2 mi

    1. Drive from Pensacola to St. Louiscar car 699.2 mi
    12h 48m
    $120–173

  5. Bus to Destin–Fort Walton Beach Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Pensacola to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL)plane plane VPS - STL
    4h 52m
    $185–671

  6. Drive to Northwest Florida Beaches International Airport, fly to Lambert–St. Louis International Airport

    1. Drive from Pensacola to Northwest Florida Beaches International Airport (ECP)car car
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Lambert–St. Louis International Airport (STL)plane plane ECP - STL
    4h 58m
    $110–578

  7. Drive to Mobile Regional Airport, fly to Lambert–St. Louis International Airport

    1. Drive from Pensacola to Mobile Regional Airport (MOB)car car
    2. Fly from Mobile Regional Airport (MOB) to Lambert–St. Louis International Airport (STL)plane plane MOB - STL
    6h 16m
    $115–620

  8. Bus to Destin–Fort Walton Beach Airport, fly to Midamerica St. Louis Airport

    1. Take the bus from Pensacola to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Midamerica St. Louis Airport (BLV)plane plane VPS - BLV
    5h 7m
    $183–530

  9. Bus via Atlanta

    1. Take the bus from Pensacola to Tallahasseebus bus
    2. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Carbondale Intermodal Stationbus bus
    4. Take the bus from Carbondale to St. Louisbus bus
    23h 48m
    $190–293

Pensacola International Airport (PNS) to Lambert–St. Louis International Airport (STL) flights

Calendar30Weekly Planes
Duration3h 45mAverage Duration
Ticket$87Cheapest Price
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Comparing Your Travel Options

Map of how to get from Pensacola to St. Louis.ExpandLaunch map view
  • Distance: 617.8 mi
  • Duration: 4h 48m

What companies run services between Pensacola, FL, USA and St. Louis, MO, USA?

Southwest Airlines and Delta fly from Pensacola International Airport (PNS) to Lambert–St. Louis International Airport (STL) 4 times a day. Alternatively, you can take a bus from Pensacola to St Louis Bus Station via Tallahassee, N Monroe Street and Silver Slipper Lane, Tallahassee, and Nashville Bus Station in around 22h 27m.

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