Rome2Rio

How to get fromPhiladelphia Airport (PHL) to Mayo Clinicby plane, train, bus, bus (Flixbus, Greyhound), car, or bus (Greyhound)

Find Transport to Mayo Clinic

See all options

There are 9 ways to get from Philadelphia Airport (PHL) to Mayo Clinic by plane, train, bus, bus (Flixbus, Greyhound), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Philadelphia International Airport (PHL) to Rochester (RST)plane plane PHL - RST
    5h 48m
    $123–630

  2. Train, bus via Milwaukee

    1. Take the train from 30th Street Station to Washington Union Stationtrain train
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Milwaukeetrain train
    4. Take the bus from Milwaukee to Rochesterbus bus
    30h 54m
    $361–1,301

  3. Bus

    1. Take the bus from Philadelphia 30th St Station to Allentown Transportation Centerbus bus
    2. Take the bus from Allentown to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    31h 2m
    $246–394

  4. Drive 1,103.2 mi

    1. Drive from Philadelphia Airport (PHL) to Mayo Cliniccar car 1,103.2 mi
    18h 21m
    $202–291

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Philadelphia International Airport (PHL) to Minneapolis–Saint Paul International Airport (MSP)plane plane PHL - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 33m
    $230–868

  6. Fly to Dane County Regional Airport-Truax Field, bus

    1. Fly from Philadelphia International Airport (PHL) to Dane County Regional Airport-Truax Field (MSN)plane plane PHL - MSN
    2. Take the bus from Madison to Rochesterbus bus
    9h 2m
    $214–908

  7. Train, bus

    1. Take the train from 30th Street Station to Washington Union Stationtrain train
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochesterbus bus
    32h 41m
    $413–1,456

  8. Bus via Baltimore

    1. Take the bus from Philadelphia to Baltimorebus bus
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    33h 52m
    $210–408

  9. Train, bus #2

    1. Take the train from 30th Street Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    38h 35m
    $398–833

Philadelphia Airport (PHL) to Mayo Clinic by train, subway, bus, and foot

Calendar7Weekly Services
Duration30h 54mAverage Duration
Ticket$361Cheapest Price
See schedules

Questions & Answers

Map of how to get from Philadelphia Airport (PHL) to Mayo Clinic.ExpandLaunch map view
  • Distance: 936.9 mi
  • Duration: 5h 48m

What companies run services between Philadelphia Airport (PHL), USA and Mayo Clinic, MN, USA?

Delta, United Airlines, and American Airlines fly from Philadelphia International Airport (PHL) to Rochester (RST) every 4 hours. Alternatively, you can take a train from Airport Terminal A to Mayo Clinic via Gray 30th St Station, Philadelphia 30th St Station, Allentown Transportation Center, Allentown, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 31h 2m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers