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How to get fromPhiladelphia to Cleveland Clinicby plane, train (Amtrak), bus (Flixbus), car, train, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Philadelphia to Cleveland Clinic by plane, train (Amtrak), bus (Flixbus), car, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Philadelphia International Airport

    best
    1. Fly from Philadelphia International Airport (PHL) to Cleveland-Hopkins International Airport (CLE)plane plane PHL - CLE
    4h 15m
    $176–436

  2. Bus via Harrisburg

    cheapest
    1. Take the bus from Philadelphia Bus Station to Harrisburg Bus Stationbus bus Greyhound US0421 / ...
    2. Take the bus from Harrisburg Bus Station to Cleveland Bus Stationbus bus Greyhound US0420
    12h 51m
    $70–144

  3. Train (Amtrak)

    1. Take the train from 30th Street Station to Pittsburgh Amtrak Stationtrain train Pennsylvanian
    2. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain train Floridian
    12h 18m
    $162–326

  4. Bus

    1. Take the bus from Philadelphia Bus Station to New York City Chinatownbus bus FlixBus 2608
    2. Take the bus from New York to Cleveland, OHbus bus New York
    12h 48m
    $115–130

  5. Drive 424.7 mi

    1. Drive from Philadelphia to Cleveland Cliniccar car 424.7 mi
    7h 12m
    $78–112

  6. Train to Newark Liberty International Airport, fly

    1. Take the train from 30th Street Station to Newark Liberty International Airporttrain train
    2. Fly from Newark Liberty International Airport (EWR) to Cleveland-Hopkins International Airport (CLE)plane plane EWR - CLE
    4h 52m
    $209–905

  7. Train to Baltimore-Washington International Airport, fly

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Cleveland-Hopkins International Airport (CLE)plane plane BWI - CLE
    4h 58m
    $147–1,261

  8. Train to Laguardia Airport, fly

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Laguardia Airport (LGA) to Cleveland-Hopkins International Airport (CLE)plane plane LGA - CLE
    6h 33m
    $152–1,316

Philadelphia to Cleveland Clinic by bus, foot, and subway

Calendar7Weekly Services
Duration12h 51mAverage Duration
Ticket$70Cheapest Price
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Questions & Answers

Map of how to get from Philadelphia to Cleveland Clinic.ExpandLaunch map view
  • Distance: 387.7 mi
  • Duration: 4h 15m

What companies run services between Philadelphia, PA, USA and Cleveland Clinic, OH, USA?

American Airlines, Delta, and United Airlines fly from Philadelphia International Airport (PHL) to Cleveland-Hopkins International Airport (CLE) every 2 hours. Alternatively, you can take a train from 30th Street Station to Cleveland Clinic via Pittsburgh Amtrak Station, Cleveland Amtrak, Tower City Station Track 13, and E 105Th St-Quincy Av Station in around 12h 18m.

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