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How to get fromPhiladelphia to Florenceby plane, bus, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

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There are 9 ways to get from Philadelphia to Florence by plane, bus, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Philadelphia International Airport to Myrtle Beach, bus

    best
    1. Fly from Philadelphia International Airport (PHL) to Myrtle Beach (MYR)plane plane PHL - MYR
    2. Take the bus from Myrtle Beach to Florencebus bus
    6h
    $128–491

  2. Bus

    cheapest
    1. Take the bus from Philadelphia Bus Station to Raleigh Bus Stationbus bus Greyhound US0670
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus Greyhound US0642 / ...
    13h 10m
    $86–163

  3. Bus via Washington

    1. Take the bus from Philadelphia Bus Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Florence Bus Stationbus bus
    12h 35m
    $110–177

  4. Train (Amtrak)

    1. Take the train from 30th Street Station to Florence Stationtrain train Palmetto / ...
    13h 11m
    $170–360

  5. Drive 535.6 mi

    1. Drive from Philadelphia to Florencecar car 535.6 mi
    9h 23m
    $98–142

  6. Bus to Lehigh Valley International Airport, fly to Myrtle Beach, bus

    1. Take the bus from Philadelphia to Allentownbus bus
    2. Fly from Lehigh Valley International Airport (ABE) to Myrtle Beach (MYR)plane plane ABE - MYR
    3. Take the bus from Myrtle Beach to Florencebus bus
    7h 41m
    $131–413

  7. Fly Philadelphia International Airport to Charleston International Airport, train

    1. Fly from Philadelphia International Airport (PHL) to Charleston International Airport (CHS)plane plane PHL - CHS
    2. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    8h 9m
    $137–622

  8. Fly Philadelphia International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Philadelphia International Airport (PHL) to Charlotte Douglas International Airport (CLT)plane plane PHL - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    8h 35m
    $136–248

  9. Fly Philadelphia International Airport to Raleigh-Durham International Airport, bus

    1. Fly from Philadelphia International Airport (PHL) to Raleigh-Durham International Airport (RDU)plane plane PHL - RDU
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus
    8h 42m
    $101–433

Philadelphia to Florence by bus

Calendar22Weekly Buses
Duration12h 35mAverage Duration
Ticket$110Cheapest Price
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Questions & Answers

Map of how to get from Philadelphia to Florence.ExpandLaunch map view
  • Distance: 560.9 mi
  • Duration: 6h

What companies run services between Philadelphia, PA, USA and Florence, SC, USA?

You can take a bus from Philadelphia Bus Station to Florence Bus Station via Washington Union Station and Fayetteville Bus Station in around 12h 35m. Alternatively, Amtrak operates a train from 30th Street Station to Florence Station twice daily. Tickets cost $170–360 and the journey takes 13h 11m.

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