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How to get fromPhiladelphia to Florenceby bus (Flixbus, Greyhound), train (Amtrak), car, plane, train, bus (Greyhound), or bus

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There are 11 ways to get from Philadelphia to Florence by bus (Flixbus, Greyhound), train (Amtrak), car, plane, train, bus (Greyhound), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Washington

    best
    1. Take the bus from Philadelphia Bus Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Florence Bus Stationbus bus
    12h 50m
    $78–130

  2. Train (Amtrak)

    1. Take the train from 30th Street Station to Florence Stationtrain train Palmetto / ...
    13h 11m
    $140–310

  3. Drive  535.6 mi

    1. Drive from Philadelphia to Florencecar car 535.6 mi
    9h 23m
    $98–142

  4. Fly Philadelphia International Airport to Charleston International Airport, train

    1. Fly from Philadelphia International Airport (PHL) to Charleston International Airport (CHS)plane plane PHL - CHS
    2. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    8h 6m
    $681–963

  5. Bus (Greyhound)

    1. Take the bus from Philadelphia Bus Station to Raleigh Bus Stationbus bus Greyhound US0670
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus Greyhound US0642S / ...
    13h 20m
    $85–137

  6. Fly Philadelphia International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Philadelphia International Airport (PHL) to Charlotte Douglas International Airport (CLT)plane plane PHL - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    8h 32m
    $136–232

  7. Fly Philadelphia International Airport to Wilmington International Airport, bus, train

    1. Fly from Philadelphia International Airport (PHL) to Wilmington International Airport (ILM)plane plane PHL - ILM
    2. Take the bus from Wilmington Cape Fear Public Transit to Fayetteville Bus Stationbus bus
    3. Take the train from Fayetteville Amtrak Station to Florence Stationtrain train
    9h 32m
    $141–651

  8. Fly Philadelphia International Airport to Myrtle Beach, bus, train

    1. Fly from Philadelphia International Airport (PHL) to Myrtle Beach (MYR)plane plane PHL - MYR
    2. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    3. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    9h 7m
    $118–748

  9. Fly Philadelphia International Airport to Columbia, bus

    1. Fly from Philadelphia International Airport (PHL) to Columbia (CAE)plane plane PHL - CAE
    2. Take the bus from Columbia, SC to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    9h 28m
    $127–550

  10. Fly Philadelphia International Airport to Raleigh-Durham International Airport, train

    1. Fly from Philadelphia International Airport (PHL) to Raleigh-Durham International Airport (RDU)plane plane PHL - RDU
    2. Take the train from Raleigh Union Station to Selma Stationtrain train
    3. Take the train from Selma Station to Florence Stationtrain train
    9h 45m
    $113–469

  11. Bus to Lehigh Valley International Airport, fly to Myrtle Beach, bus, train

    1. Take the bus from Philadelphia 30th St Station to Allentown Transportation Centerbus bus
    2. Fly from Lehigh Valley International Airport (ABE) to Myrtle Beach (MYR)plane plane ABE - MYR
    3. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    4. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    10h 55m
    $137–468

Philadelphia to Florence by bus

Calendar14Weekly Buses
Duration12h 50mAverage Duration
Ticket$78Cheapest Price
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Comparing Your Travel Options

Map of how to get from Philadelphia to Florence.ExpandLaunch map view
  • Distance: 550.2 mi
  • Duration: 12h 50m

What companies run services between Philadelphia, PA, USA and Florence, SC, USA?

You can take a bus from Philadelphia Bus Station to Florence Bus Station via Washington Union Station and Fayetteville Bus Station in around 12h 50m. Alternatively, Amtrak operates a train from 30th Street Station to Florence Station twice daily. Tickets cost $140–310 and the journey takes 13h 11m.

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