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How to get fromPhiladelphia to Florenceby plane, bus, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

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There are 7 ways to get from Philadelphia to Florence by plane, bus, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Myrtle Beach, bus

    best
    1. Fly from Philadelphia International Airport (PHL) to Myrtle Beach (MYR)plane plane PHL - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    5h 50m
    $89–685

  2. Bus via Washington

    cheapest
    1. Take the bus from Philadelphia Bus Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Florence Bus Stationbus bus
    12h 50m
    $80–131

  3. Train (Amtrak)

    1. Take the train from 30th Street Station to Florence Stationtrain train Palmetto / ...
    13h 11m
    $140–350

  4. Drive  535.6 mi

    1. Drive from Philadelphia to Florencecar car 535.6 mi
    9h 23m
    $98–142

  5. Fly to Charleston International Airport, train

    1. Fly from Philadelphia International Airport (PHL) to Charleston International Airport (CHS)plane plane PHL - CHS
    2. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    8h 7m
    $681–968

  6. Fly to Charlotte Douglas International Airport, bus

    1. Fly from Philadelphia International Airport (PHL) to Charlotte Douglas International Airport (CLT)plane plane PHL - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    8h 34m
    $136–243

  7. Bus (Greyhound)

    1. Take the bus from Philadelphia Bus Station to Raleigh Bus Stationbus bus Greyhound US0670
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus Greyhound US0642S / ...
    13h 20m
    $88–139

Philadelphia to Florence by bus

Calendar14Weekly Buses
Duration12h 50mAverage Duration
Ticket$80Cheapest Price
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Comparing Your Travel Options

Map of how to get from Philadelphia to Florence.ExpandLaunch map view
  • Distance: 553 mi
  • Duration: 5h 50m

What companies run services between Philadelphia, PA, USA and Florence, SC, USA?

You can take a bus from Philadelphia Bus Station to Florence Bus Station via Washington Union Station and Fayetteville Bus Station in around 12h 50m. Alternatively, Amtrak operates a train from 30th Street Station to Florence Station twice daily. Tickets cost $140–350 and the journey takes 13h 11m.

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Bus operators

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