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How to get fromPhiladelphia to Mayo Clinicby plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Greyhound)

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There are 11 ways to get from Philadelphia to Mayo Clinic by plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Philadelphia International Airport to Rochester

    best
    1. Fly from Philadelphia International Airport (PHL) to Rochester (RST)plane plane PHL - RST
    7h 39m
    $134–694

  2. Bus

    1. Take the bus from Philadelphia Bus Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    29h 21m
    $233–344

  3. Train, bus via Milwaukee

    1. Take the train from 30th Street Station to Washington Union Stationtrain train
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Milwaukeetrain train
    4. Take the bus from Milwaukee to Rochesterbus bus
    30h 16m
    $558–1,461

  4. Drive  1,104.7 mi

    1. Drive from Philadelphia to Mayo Cliniccar car 1,104.7 mi
    18h 7m
    $189–273

  5. Fly Philadelphia International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Philadelphia International Airport (PHL) to Minneapolis–Saint Paul International Airport (MSP)plane plane PHL - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 30m
    $213–904

  6. Train to Newark Liberty International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from 30th Street Station to Newark Liberty International Airporttrain train
    2. Fly from Newark Liberty International Airport (EWR) to Minneapolis–Saint Paul International Airport (MSP)plane plane EWR - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    8h 17m
    $273–966

  7. Train to Baltimore-Washington International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Minneapolis–Saint Paul International Airport (MSP)plane plane BWI - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    8h 28m
    $204–1,358

  8. Train to John F. Kennedy International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Minneapolis–Saint Paul International Airport (MSP)plane plane JFK - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 23m
    $505–1,665

  9. Train, bus

    1. Take the train from 30th Street Station to Washington Union Stationtrain train
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochesterbus bus
    32h 3m
    $691–1,676

  10. Bus via Baltimore

    1. Take the bus from Philadelphia Bus Station to Baltimore Greyhound Garagebus bus
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    34h 31m
    $237–387

  11. Train, bus #2

    1. Take the train from 30th Street Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    36h 54m
    $650–1,012

Philadelphia to Mayo Clinic by bus and foot

Calendar6Weekly Services
Duration29h 21mAverage Duration
Ticket$233Cheapest Price
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Comparing Your Travel Options

Map of how to get from Philadelphia to Mayo Clinic.ExpandLaunch map view
  • Distance: 945.7 mi
  • Duration: 7h 39m

What companies run services between Philadelphia, PA, USA and Mayo Clinic, MN, USA?

Delta and American Airlines fly from Philadelphia International Airport (PHL) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Philadelphia Bus Station to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 29h 21m.

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