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How to get fromPhiladelphia to Saint Charlesby plane, bus (Greyhound), train (Amtrak), car, or train

Find Transport to Saint Charles

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There are 7 ways to get from Philadelphia to Saint Charles by plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Philadelphia International Airport

    best
    1. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    4h 49m
    $157–757

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Philadelphia Bus Station to St Louis Bus Stationbus bus Greyhound US0421
    22h 38m
    $144–264

  3. Train (Amtrak)

    1. Take the train from 30th Street Station to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    34h 21m
    $440–876

  4. Drive 895.9 mi

    1. Drive from Philadelphia to Saint Charlescar car 895.9 mi
    15h 18m
    $164–237

  5. Train to Baltimore-Washington International Airport, fly

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Lambert–St. Louis International Airport (STL)plane plane BWI - STL
    5h 51m
    $158–1,312

  6. Train to Newark Liberty International Airport, fly

    1. Take the train from 30th Street Station to Newark Liberty International Airporttrain train
    2. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)plane plane EWR - STL
    5h 45m
    $380–1,055

  7. Train to Ronald Reagan Washington National Airport, fly

    1. Take the train from 30th Street Station to Washington Union Stationtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Lambert–St. Louis International Airport (STL)plane plane DCA - STL
    6h 40m
    $169–1,024

Philadelphia to Saint Charles by bus (Greyhound)

Calendar21Weekly Buses
Duration22h 38mAverage Duration
Ticket$144Cheapest Price
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Questions & Answers

Map of how to get from Philadelphia to Saint Charles.ExpandLaunch map view
  • Distance: 833.8 mi
  • Duration: 4h 49m

What companies run services between Philadelphia, PA, USA and Saint Charles, MO, USA?

American Airlines, Southwest Airlines, and Delta fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, Greyhound USA operates a bus from Philadelphia Bus Station to St Louis Bus Station 3 times a day. Tickets cost $140–270 and the journey takes 20h 50m.

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