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How to get fromPhiladelphia to Santeeby plane, car, train, bus (Greyhound, Flixbus), or bus (Flixbus)

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There are 7 ways to get from Philadelphia to Santee by plane, car, train, bus (Greyhound, Flixbus), or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Philadelphia International Airport to Charleston International Airport, drive

    best
    1. Fly from Philadelphia International Airport (PHL) to Charleston International Airport (CHS)plane plane PHL - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    4h 27m
    $113–569

  2. Drive 601.9 mi

    cheapest
    1. Drive from Philadelphia to Santeecar car 601.9 mi
    10h 25m
    $110–159

  3. Train, drive (Amtrak)

    1. Take the train from 30th Street Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    2. Drive from Charleston Amtrak Station to Santeecar car
    13h 34m
    $217–430

  4. Bus

    1. Take the bus from Philadelphia Bus Station to Charlotte Bus Stationbus bus Greyhound US0670
    2. Take the bus from Charlotte to Orangeburgbus bus Ses 996 / ...
    18h 32m
    $181–297

  5. Fly Philadelphia International Airport to Columbia, drive

    1. Fly from Philadelphia International Airport (PHL) to Columbia (CAE)plane plane PHL - CAE
    2. Drive from Columbia-Airport-CAE to Santeecar car
    4h 30m
    $233–1,319

  6. Train to Newark Liberty International Airport, fly to Charleston International Airport, drive

    1. Take the train from 30th Street Station to Newark Liberty International Airporttrain train
    2. Fly from Newark Liberty International Airport (EWR) to Charleston International Airport (CHS)plane plane EWR - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    5h 23m
    $406–1,167

  7. Bus via Fredericksburg

    1. Take the bus from Philadelphia Bus Station to Fredericksburgbus bus
    2. Take the bus from Fredericksburg to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Orangeburgbus bus
    18h 47m
    $191–295

Philadelphia International Airport (PHL) to Charleston International Airport (CHS) flights

Calendar72Weekly Planes
Duration3h 48mAverage Duration
Ticket$102Cheapest Price
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Questions & Answers

Map of how to get from Philadelphia to Santee.ExpandLaunch map view
  • Distance: 619.5 mi
  • Duration: 4h 27m

What companies run services between Philadelphia, PA, USA and Santee, SC, USA?

You can take a bus from Philadelphia Bus Station to Santee via Charlotte and Orangeburg in around 18h 32m.

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Train operators
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