There are 4 ways to get from Phoenix to Otay Mesa by plane, tram, bus (Greyhound), car, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly, tram
best- Fly from Phoenix (PHX) to San Diego International Airport (SAN)plane PHX - SAN
- Take the tram from America Plaza Station to Iris Avenue Stationtram
4h 7m$76–264Bus (Greyhound)
cheapest- Take the bus from Phoenix Bus Station to San Ysidro Bus Terminalbus Greyhound US0851S
9h 10m$63–101Drive 345.8 mi
- Drive from Phoenix to Otay Mesacar 345.8 mi
6h 4m$64–92Bus via El Centro
- Take the bus from Phoenix Sky Harbor Airport/44th Street Sky Train Station to El Centro Bus Stopbus FlixBus 2054
- Take the bus from El Centro Bus Stop to San Ysidro Bus Terminalbus Greyhound US0851S
10h 26m$63–102
Phoenix to Otay Mesa by bus and tram (Greyhound)
Comparing Your Travel Options
The cheapest way to get from Phoenix to Otay Mesa is to bus which costs $60 - $110 and takes 9h 10m.
The fastest way to get from Phoenix to Otay Mesa is to fly and tram which takes 4h 7m and costs $75 - $270.
No, there is no direct bus from Phoenix station to Otay Mesa. However, there are services departing from Phoenix Bus Station and arriving at Otay Mesa Rd & Cactus Rd via Iris Avenue Transit Center. The journey, including transfers, takes approximately 9h 10m.
The distance between Phoenix and Otay Mesa is 332 miles. The road distance is 347.8 miles.
The best way to get from Phoenix to Otay Mesa without a car is to bus which takes 9h 10m and costs $60 - $110.
It takes approximately 4h 7m to get from Phoenix to Otay Mesa, including transfers.
Phoenix to Otay Mesa bus services, operated by Greyhound USA, depart from Phoenix Bus Station.
Phoenix to Otay Mesa bus services, operated by Greyhound USA, arrive at San Ysidro Bus Terminal station.
Yes, the driving distance between Phoenix to Otay Mesa is 348 miles. It takes approximately 6h 4m to drive from Phoenix to Otay Mesa.
There are 572+ hotels available in Otay Mesa.
What companies run services between Phoenix, AZ, USA and Otay Mesa, CA, USA?
Greyhound USA operates a bus from Phoenix Bus Station to San Ysidro Bus Terminal once daily. Tickets cost $60–100 and the journey takes 8h 25m.
- Website
- southwest.com
Flights from Phoenix to San Diego International Airport
- Ave. Duration
- 1h 14m
- When
- Every day
- Estimated price
- $35–260
Flights from Phoenix to San Diego International Airport via Las Vegas
- Ave. Duration
- 3h 20m
- When
- Sunday, Monday, Thursday, and Friday
- Estimated price
- $50–290
- Phone
- +1 619-557-4555
- Website
- MTS
Tram from America Plaza Station to Iris Avenue Station
- Ave. Duration
- 38 min
- Frequency
- Every 15 minutes
- Estimated price
- $2–14
- Website
- MTS
- Schedules at
- MTS Schedules
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Phoenix Bus Station to San Ysidro Bus Terminal
- Ave. Duration
- 8h 25m
- Frequency
- Once daily
- Estimated price
- $60–100
- Website
- Greyhound
Bus from El Centro Bus Stop to San Ysidro Bus Terminal
- Ave. Duration
- 3h 5m
- Frequency
- Once daily
- Estimated price
- $21–35
- Website
- Greyhound
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