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How to get fromPittsburgh Amtrak Station to Chicago Union Stationby bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Flixbus)

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There are 8 ways to get from Pittsburgh Amtrak Station to Chicago Union Station by bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Pittsburgh International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Chicago Midway International Airport (MDW)plane plane PIT - MDW
    4h 29m

  2. Bus

    cheapest
    1. Take the bus from Pittsburgh Intermodal Station to Chicago Bus Stationbus bus Greyhound US0164
    10h 14m
    $70–140

  3. Train (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    9h 46m
    $140–320

  4. Drive 460.5 mi

    1. Drive from Pittsburgh Amtrak Station to Chicago Union Stationcar car 460.5 mi
    7h 37m
    $84–122

  5. Bus to Pittsburgh International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Chicago O'Hare International Airport (ORD)plane plane PIT - ORD
    4h 59m

  6. Train to Johnstown-Cambria County Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Pittsburgh Amtrak Station to Johnstown Amtrak Stationtrain train
    2. Fly from Johnstown-Cambria County Airport (JST) to Chicago O'Hare International Airport (ORD)plane plane JST - ORD
    5h 40m
    $85–363

  7. Train to Cleveland-Hopkins International Airport, fly to Chicago Midway International Airport

    1. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Chicago Midway International Airport (MDW)plane plane CLE - MDW
    6h 52m
    $103–478

  8. Bus via Chicago (Flixbus)

    1. Take the bus from Pittsburgh Intermodal Station to Chicagobus bus FlixBus N2640
    11h 36m
    $85–139

Pittsburgh Amtrak Station to Chicago Union Station by train (Amtrak)

Calendar7Weekly Trains
Duration9h 46mAverage Duration
Ticket$140Cheapest Price
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Questions & Answers

Map of how to get from Pittsburgh Amtrak Station to Chicago Union Station.ExpandLaunch map view
  • Distance: 436.9 mi
  • Duration: 4h 29m

What companies run services between Pittsburgh Amtrak Station, PA, USA and Chicago Union Station, IL, USA?

Amtrak operates a train from Pittsburgh Amtrak Station to Chicago Union Station once daily. Tickets cost $140–320 and the journey takes 9h 46m. Alternatively, Greyhound USA operates a bus from Pittsburgh Intermodal Station to Chicago Bus Station twice daily. Tickets cost $70–140 and the journey takes 10h 5m. Flixbus USA also services this route once daily.

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