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How to get fromPittsburgh, Pa to Chicagoby bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, or train

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There are 8 ways to get from Pittsburgh, Pa to Chicago by bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Pittsburgh International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Chicago Midway International Airport (MDW)plane plane PIT - MDW
    4h 28m

  2. Bus to Morgantown Municipal Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from Pittsburgh Greyhound to Westover Terminalbus bus
    2. Fly from Morgantown Municipal Airport (MGW) to Chicago O'Hare International Airport (ORD)plane plane MGW - ORD
    7h 8m
    $51–306

  3. Train (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    9h 46m
    $260–410

  4. Bus

    1. Take the bus from Pittsburgh Intermodal Station to Chicago Bus Stationbus bus Greyhound US0164
    10h 5m
    $75–140

  5. Drive  460 mi

    1. Drive from Pittsburgh, Pa to Chicagocar car 460 mi
    7h 36m
    $79–114

  6. Bus to Pittsburgh International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Chicago O'Hare International Airport (ORD)plane plane PIT - ORD
    4h 52m

  7. Train to Johnstown-Cambria County Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Pittsburgh Amtrak Station to Johnstown Amtrak Stationtrain train
    2. Fly from Johnstown-Cambria County Airport (JST) to Chicago O'Hare International Airport (ORD)plane plane JST - ORD
    5h 35m
    $103–368

  8. Train to Cleveland-Hopkins International Airport, fly to Chicago Midway International Airport

    1. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Chicago Midway International Airport (MDW)plane plane CLE - MDW
    6h 48m
    $146–565

Pittsburgh, Pa to Chicago by train (Amtrak)

Calendar7Weekly Trains
Duration9h 46mAverage Duration
Ticket$260Cheapest Price
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Comparing Your Travel Options

Map of how to get from Pittsburgh, Pa to Chicago.ExpandLaunch map view
  • Distance: 436.1 mi
  • Duration: 4h 28m

What companies run services between Pittsburgh, Pa, PA, USA and Chicago, IL, USA?

Amtrak operates a train from Pittsburgh Amtrak Station to Chicago Union Station once daily. Tickets cost $260–410 and the journey takes 9h 46m. Alternatively, Greyhound USA operates a bus from Pittsburgh Intermodal Station to Chicago Bus Station 4 times a day. Tickets cost $85–140 and the journey takes 10h 5m. Flixbus USA also services this route 3 times a day.

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