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How to get fromPittsburgh to Buffalo Depew Stationby train (Amtrak), bus (Greyhound), car, plane, or bus

Find Transport to Buffalo Depew Station

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There are 5 ways to get from Pittsburgh to Buffalo Depew Station by train (Amtrak), bus (Greyhound), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain train Floridian
    2. Take the train from Cleveland Amtrak to Buffalo Depew Stationtrain train Lake Shore Limited
    6h 57m
    $105–221

  2. Bus via Erie

    cheapest
    1. Take the bus from Pittsburgh Intermodal Station to Eriebus bus Greyhound US0440s
    2. Take the bus from Erie, PA to Buffalo, NYbus bus Cinncinati,OH-Buffalo
    8h 8m
    $39–71

  3. Drive 217.8 mi

    1. Drive from Pittsburgh to Buffalo Depew Stationcar car 217.8 mi
    3h 46m
    $40–58

  4. Fly

    1. Fly from Pittsburgh International Airport (PIT) to Buffalo Niagara International Airport (BUF)plane plane PIT - BUF
    5h 33m
    $124–647

  5. Bus

    1. Take the bus from Pittsburgh to Buffalobus bus Fab510 / ...
    10h 16m
    $106–190

Pittsburgh to Buffalo Depew Station by train (Amtrak)

Calendar7Weekly Trains
Duration6h 57mAverage Duration
Ticket$105Cheapest Price
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Questions & Answers

Map of how to get from Pittsburgh to Buffalo Depew Station.ExpandLaunch map view
  • Distance: 324.4 mi
  • Duration: 6h 57m

What companies run services between Pittsburgh, PA, USA and Buffalo Depew Station, NY, USA?

You can take a train from Pittsburgh Amtrak Station to Buffalo Depew Station via Cleveland Amtrak in around 6h 57m. Alternatively, you can take a bus from Pittsburgh Intermodal Station to Buffalo Depew Station via Erie, Erie, PA, Ellicott Street & MTC Static, Walden Avenue & Thruway Transit Center, and Walden Avenue & 2929 Walden Avenue in around 8h 8m.

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