There are 8 ways to get from Pittsburgh to Cairo by plane, taxi, bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Barkley Regional Airport, taxi
best- Fly from Pittsburgh International Airport (PIT) to Barkley Regional Airport (PAH)plane PIT - PAH
- Take the taxi from Barkley Regional Airport (PAH) to Cairotaxi
8h 17m$158–536Drive 632.8 mi
cheapest- Drive from Pittsburgh to Cairocar 632.8 mi
10h 49m$116–167Bus, taxi
- Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Cape Girardeaubus
- Take the taxi from Cape Girardeau to Cairotaxi
16h 52m$252–333Train, taxi
- Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Carbondaletrain
- Take the taxi from Carbondale to Cairotaxi
17h 17m$375–671Fly to Williamson County Regional Airport, taxi
- Fly from Pittsburgh International Airport (PIT) to Williamson County Regional Airport (MWA)plane PIT - MWA
- Take the taxi from Williamson County Regional Airport (MWA) to Cairotaxi
7h 10m$214–626Fly to Lambert–St. Louis International Airport, bus, taxi
- Fly from Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL)plane PIT - STL
- Take the bus from St Louis Bus Station to Cape Girardeaubus
- Take the taxi from Cape Girardeau to Cairotaxi
8h 33m$229–739Fly to Nashville, bus, taxi
- Fly from Pittsburgh International Airport (PIT) to Nashville (BNA)plane PIT - BNA
- Take the bus from Nashville Bus Station to Paducah Bus Stationbus
- Take the taxi from Paducah Bus Station to Cairotaxi
8h 36m$747–1,160Bus, taxi via Auburn Gresham
- Take the bus from Pittsburgh Intermodal Station to Chicagobus
- Take the bus from Chicago to Paducah Bus Stationbus
- Take the taxi from Paducah Bus Station to Cairotaxi
22h 30m$282–411
Pittsburgh International Airport (PIT) to Barkley Regional Airport (PAH) flights
Questions & Answers
The cheapest way to get from Pittsburgh to Cairo is to drive which costs $110 - $170 and takes 10h 49m.
The fastest way to get from Pittsburgh to Cairo is to fly and taxi which takes 7h 10m and costs $210 - $650.
The distance between Pittsburgh and Cairo is 573 miles. The road distance is 636.5 miles.
The best way to get from Pittsburgh to Cairo without a car is to bus and taxi which takes 16h 52m and costs $250 - $340.
It takes approximately 8h 17m to get from Pittsburgh to Cairo, including transfers.
Cairo is 1h behind Pittsburgh. It is currently 1:31 AM in Pittsburgh and 12:31 AM in Cairo.
Yes, the driving distance between Pittsburgh to Cairo is 636 miles. It takes approximately 10h 49m to drive from Pittsburgh to Cairo.
There are four+ hotels available in Cairo.
What companies run services between Pittsburgh, PA, USA and Cairo, IL, USA?
There is no direct connection from Pittsburgh to Cairo. However, you can take the bus to Pittsburgh International Airport, walk to Pittsburgh-Airport-PIT airport, fly to Barkley Regional Airport (PAH), then take the taxi to Cairo. Alternatively, you can take the bus to St Louis Bus Station, take the bus to Cape Girardeau, then take the taxi to Cairo.
- Website
- southwest.com
Flights from Pittsburgh International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $110–600
Flights from Pittsburgh International Airport to Lambert–St. Louis International Airport via Chicago Midway
- Ave. Duration
- 3h 39m
- When
- Every day
- Estimated price
- $120–650
Flights from Pittsburgh International Airport to Lambert–St. Louis International Airport via Nashville
- Ave. Duration
- 3h 47m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $130–700
Flights from Pittsburgh International Airport to Nashville
- Ave. Duration
- 1h 34m
- When
- Every day
- Estimated price
- $75–430
Flights from Pittsburgh International Airport to Nashville via Chicago Midway
- Ave. Duration
- 3h 40m
- When
- Monday, Thursday, and Friday
- Estimated price
- $100–550
- Website
- delta.com
Flights from Pittsburgh International Airport to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 3h 53m
- When
- Every day
- Estimated price
- $120–650
Flights from Pittsburgh International Airport to Nashville via Detroit
- Ave. Duration
- 3h 47m
- When
- Every day
- Estimated price
- $90–480
Flights from Pittsburgh International Airport to Nashville via Atlanta
- Ave. Duration
- 3h 58m
- When
- Every day
- Estimated price
- $100–500
- Website
- united.com
Flights from Pittsburgh International Airport to Barkley Regional Airport via Chicago O'Hare
- Ave. Duration
- 5h 44m
- When
- Every day
- Estimated price
- $90–460
Flights from Pittsburgh International Airport to Barkley Regional Airport via Houston
- Ave. Duration
- 7h 10m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $170–700
Flights from Pittsburgh International Airport to Barkley Regional Airport via Washington Dulles, Chicago O'Hare
- Ave. Duration
- 8h
- When
- Every day
- Estimated price
- $120–550
Flights from Pittsburgh International Airport to Barkley Regional Airport via Toronto, Chicago O'Hare
- Ave. Duration
- 8h 10m
- When
- Every day
- Estimated price
- $110–550
Flights from Pittsburgh International Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 12m
- When
- Every day
- Estimated price
- $120–650
- Website
- aa.com
Flights from Pittsburgh International Airport to Williamson County Regional Airport via Chicago O'Hare
- Ave. Duration
- 4h 46m
- When
- Every day
- Estimated price
- $90–470
- Website
- contouraviation.com
Flights from Pittsburgh International Airport to Williamson County Regional Airport via Chicago O'Hare
- Ave. Duration
- 5h 3m
- When
- Every day
- Estimated price
- $90–470
- Website
- allegiantair.com
Flights from Pittsburgh International Airport to Nashville
- Ave. Duration
- 1h 39m
- When
- Thursday and Sunday
- Estimated price
- $75–430
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Pittsburgh Amtrak Station to Chicago Union Station
- Ave. Duration
- 9h 46m
- Frequency
- Once daily
- Estimated price
- $150–320
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Carbondale
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- $100–210
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Pittsburgh Intermodal Station to St Louis Bus Station
- Ave. Duration
- 12h 55m
- Frequency
- 3 times a day
- Estimated price
- $95–190
- Website
- https://www.greyhound.com/
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $18–35
- Website
- https://www.greyhound.com/
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $18–35
- Website
- https://www.greyhound.com/
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Pittsburgh Intermodal Station to St Louis Bus Station
- Ave. Duration
- 12h 55m
- Frequency
- 3 times a day
- Estimated price
- $130–190
- Book at
- https://www.jeffersonlines.com
- Adult
- $130–190
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $35–50
- Book at
- https://www.jeffersonlines.com
- Adult
- $35–50
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $35–50
- Book at
- https://www.jeffersonlines.com
- Adult
- $35–50
Bus from Nashville Bus Station to Paducah Bus Station
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- $40–60
- Book at
- https://www.jeffersonlines.com
- Adult
- $40–60
Bus from Pittsburgh Intermodal Station to Chicago
- Ave. Duration
- 10h 55m
- Frequency
- Once daily
- Estimated price
- $120–170
- Book at
- https://www.jeffersonlines.com
- Adult
- $120–170
Bus from Chicago to Paducah Bus Station
- Ave. Duration
- 9h 45m
- Frequency
- Once daily
- Estimated price
- $110–160
- Book at
- https://www.jeffersonlines.com
- Adult
- $110–160
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Nashville Bus Station to Paducah Bus Station
- Ave. Duration
- 2h 25m
- Frequency
- 5 times a week
- Estimated price
- $21–35
- Schedules at
- flixbus.com
Bus from Pittsburgh Intermodal Station to Chicago
- Ave. Duration
- 10h 55m
- Frequency
- 6 times a week
- Estimated price
- $85–150
- Schedules at
- flixbus.com
- Ave. Duration
- 52 min
- Estimated price
- $65–160
Howard's Taxi Full Throttle
- Phone
- +1-573-270-9932
Ace Taxi
- Phone
- +1 216-361-4700
- Website
- acetaxi.com
Ace Taxi
- Phone
- +1 216-361-4700
- Website
- acetaxi.com
Howard's Taxi Full Throttle
- Phone
- +1-573-270-9932
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide









