There are 10 ways to get from Pittsburgh to Chicago Loop by bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Pittsburgh International Airport, fly to Chicago Midway International Airport
best- Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus
- Fly from Pittsburgh International Airport (PIT) to Chicago Midway International Airport (MDW)plane PIT - MDW
4h 22mBus to Morgantown Municipal Airport, fly to Chicago O'Hare International Airport
cheapest- Take the bus from Pittsburgh Greyhound to Westover Terminalbus
- Fly from Morgantown Municipal Airport (MGW) to Chicago O'Hare International Airport (ORD)plane MGW - ORD
6h 59m$46–306Train (Amtrak)
- Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain Floridian
9h 46m$110–280Bus
- Take the bus from Pittsburgh Intermodal Station to Chicago Bus Stationbus Greyhound US0164
10h 17m$75–120Drive 460.8 mi
- Drive from Pittsburgh to Chicago Loopcar 460.8 mi
7h 37m$85–122Bus to Pittsburgh International Airport, fly to Chicago O'Hare International Airport
- Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus
- Fly from Pittsburgh International Airport (PIT) to Chicago O'Hare International Airport (ORD)plane PIT - ORD
4h 37mTrain to Johnstown-Cambria County Airport, fly to Chicago O'Hare International Airport
- Take the train from Pittsburgh Amtrak Station to Johnstown Amtrak Stationtrain
- Fly from Johnstown-Cambria County Airport (JST) to Chicago O'Hare International Airport (ORD)plane JST - ORD
5h 30m$80–347Train to Cleveland-Hopkins International Airport, fly to Chicago Midway International Airport
- Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain
- Fly from Cleveland-Hopkins International Airport (CLE) to Chicago Midway International Airport (MDW)plane CLE - MDW
6h 46m$94–477Bus to Akron, fly to Chicago O'Hare International Airport
- Take the bus from Pittsburgh Intermodal Station to Robert K Pfaff Transit Center - Akronbus
- Fly from Akron (CAK) to Chicago O'Hare International Airport (ORD)plane CAK - ORD
7h 7m$55–263Bus via Chicago (Flixbus)
- Take the bus from Pittsburgh Intermodal Station to Chicagobus FlixBus N2640
11h 26m$82–125
Pittsburgh to Chicago Loop by train (Amtrak)
Comparing Your Travel Options
The cheapest way to get from Pittsburgh to Chicago Loop is to bus which costs $70 - $120 and takes 10h 17m.
The fastest way to get from Pittsburgh to Chicago Loop is to train and fly which takes 5h 30m and costs $75 - $350.
No, there is no direct bus from Pittsburgh station to Chicago Loop. However, there are services departing from Pittsburgh Intermodal Station and arriving at Washington & Lasalle via Jefferson & Harrison. The journey, including transfers, takes approximately 10h 17m.
Yes, there is a direct train departing from Pittsburgh Amtrak Station station and arriving at Chicago Union Station station. Services depart once daily, and operate every day. The journey takes approximately 9h 46m.
The distance between Pittsburgh and Chicago Loop is 439 miles. The road distance is 463.5 miles.
The best way to get from Pittsburgh to Chicago Loop without a car is to train which takes 9h 46m and costs $110 - $280.
It takes approximately 4h 22m to get from Pittsburgh to Chicago Loop, including transfers.
Pittsburgh to Chicago Loop bus services, operated by Greyhound USA, depart from Pittsburgh Intermodal Station.
Pittsburgh to Chicago Loop train services, operated by Amtrak, depart from Pittsburgh Amtrak Station.
The best way to get from Pittsburgh to Chicago Loop is to train which takes 9h 46m and costs $110 - $280. Alternatively, you can bus, which costs $70 - $120 and takes 10h 17m.
What companies run services between Pittsburgh, PA, USA and Chicago Loop, IL, USA?
Amtrak operates a train from Pittsburgh Amtrak Station to Chicago Union Station once daily. Tickets cost $110–280 and the journey takes 9h 46m. Alternatively, Greyhound USA operates a bus from Pittsburgh Intermodal Station to Chicago Bus Station twice daily. Tickets cost $75–120 and the journey takes 10h 5m. Flixbus USA also services this route once daily.
- Website
- united.com
Flights from Pittsburgh International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 47m
- When
- Every day
- Estimated price
- $50–330
Flights from Johnstown-Cambria County Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 5m
- When
- Every day
- Estimated price
- $45–280
Flights from Johnstown-Cambria County Airport to Chicago O'Hare International Airport via Washington Dulles
- Ave. Duration
- 4h 23m
- When
- Every day
- Estimated price
- $55–310
Flights from Morgantown Municipal Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 56m
- When
- Every day
- Estimated price
- $40–270
Flights from Morgantown Municipal Airport to Chicago O'Hare International Airport via Washington Dulles
- Ave. Duration
- 4h 8m
- When
- Every day
- Estimated price
- $55–310
Flights from Akron to Chicago O'Hare International Airport
- Ave. Duration
- 1h 39m
- When
- Every day
- Estimated price
- $35–230
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Pittsburgh Amtrak Station to Chicago Union Station
- Ave. Duration
- 9h 46m
- Frequency
- Once daily
- Estimated price
- $110–280
- Website
- Amtrak
Train from Pittsburgh Amtrak Station to Johnstown Amtrak Station
- Ave. Duration
- 1h 32m
- Frequency
- Once daily
- Estimated price
- $18–45
- Website
- Amtrak
Train from Pittsburgh Amtrak Station to Cleveland Amtrak
- Ave. Duration
- 2h 54m
- Frequency
- Once daily
- Estimated price
- $30–80
- Website
- Amtrak
- Phone
- +1 412-442-2000
- Website
- Pittsburgh Regional Transit
Bus from Seventh Ave + Smithfield St to Pittsburgh International Airport
- Ave. Duration
- 43 min
- Frequency
- Every 30 minutes
- Website
- Pittsburgh Regional Transit
Bus from Seventh Ave + Smithfield St to Pittsburgh International Airport
- Ave. Duration
- 43 min
- Frequency
- Every 30 minutes
- Website
- Pittsburgh Regional Transit
Want to know more about travelling around United States
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Booking & Getting There
Pittsburgh to Chicago Loop bus services, operated by Greyhound USA, arrive at Chicago Bus Station.
Chicago Loop is 1h behind Pittsburgh. It is currently 6:16 AM in Pittsburgh and 5:16 AM in Chicago Loop.
Pittsburgh to Chicago Loop train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Pittsburgh to Chicago Loop is 464 miles. It takes approximately 7h 37m to drive from Pittsburgh to Chicago Loop.
Book your Pittsburgh to Chicago Loop train tickets online with Omio.
There are 1286+ hotels available in Chicago Loop.