There are 4 ways to get from Pittsburgh to Cleveland Clinic by bus (Greyhound), train (Amtrak), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus (Greyhound)
best- Take the bus from Pittsburgh Intermodal Station to Cleveland Bus Stationbus Greyhound US0164 / ...
3h 21m$28–39Drive 126.4 mi
cheapest- Drive from Pittsburgh to Cleveland Cliniccar 126.4 mi
2h 20m$22–32Train (Amtrak)
- Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain Floridian
3h 55m$79–119Bus via Akron
- Take the bus from Pittsburgh Intermodal Station to Robert K Pfaff Transit Center - Akronbus Greyhound US0164
- Take the bus from RKP Transit Center to Euclid Ave & E. 100th St @ Cleveland Clinicbus 61
4h 48m$26–36
Pittsburgh to Cleveland Clinic by bus, foot, and subway (Greyhound)
Comparing Your Travel Options
The cheapest way to get from Pittsburgh to Cleveland Clinic is to drive which costs $21 - $35 and takes 2h 20m.
The fastest way to get from Pittsburgh to Cleveland Clinic is to drive which takes 2h 20m and costs $21 - $35.
No, there is no direct bus from Pittsburgh station to Cleveland Clinic station. However, there are services departing from Pittsburgh Intermodal Station and arriving at Cleveland Bus Station via . The journey, including transfers, takes approximately 3h 21m.
No, there is no direct train from Pittsburgh station to Cleveland Clinic station. However, there are services departing from Pittsburgh Amtrak Station and arriving at E 105Th St-Quincy Av Station via Tower City Station Track 13. The journey, including transfers, takes approximately 3h 55m.
The distance between Pittsburgh and Cleveland Clinic is 151 miles. The road distance is 127.2 miles.
The best way to get from Pittsburgh to Cleveland Clinic without a car is to bus which takes 3h 21m and costs $27 - $40.
It takes approximately 3h 21m to get from Pittsburgh to Cleveland Clinic, including transfers.
Pittsburgh to Cleveland Clinic bus services, operated by Greyhound USA, depart from Pittsburgh Intermodal Station.
Pittsburgh to Cleveland Clinic train services, operated by Amtrak, depart from Pittsburgh Amtrak Station.
The best way to get from Pittsburgh to Cleveland Clinic is to bus which takes 3h 21m and costs $27 - $40. Alternatively, you can train, which costs $75 - $120 and takes 3h 55m.
What companies run services between Pittsburgh, PA, USA and Cleveland Clinic, OH, USA?
Greyhound USA operates a bus from Pittsburgh Intermodal Station to Cleveland Bus Station every 4 hours. Tickets cost $24–40 and the journey takes 2h 10m. Alternatively, Amtrak operates a train from Pittsburgh Amtrak Station to Cleveland Amtrak once daily. Tickets cost $75–120 and the journey takes 2h 54m.
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Pittsburgh Amtrak Station to Cleveland Amtrak
- Ave. Duration
- 2h 54m
- Frequency
- Once daily
- Estimated price
- $75–120
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Pittsburgh Intermodal Station to Cleveland Bus Station
- Ave. Duration
- 2h 10m
- Frequency
- Every 4 hours
- Estimated price
- $24–40
- Website
- Greyhound
Bus from Pittsburgh Intermodal Station to Robert K Pfaff Transit Center - Akron
- Ave. Duration
- 2h 25m
- Frequency
- Twice daily
- Estimated price
- $21–35
- Website
- Greyhound
- Website
- yourmetrobus.org
Bus from RKP Transit Center to Euclid Ave & E. 100th St @ Cleveland Clinic
- Ave. Duration
- 1h 20m
- Frequency
- 4 times a day
- Estimated price
- $5
- Schedules at
- yourmetrobus.org
Want to know more about travelling around United States
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Booking & Getting There
Pittsburgh to Cleveland Clinic bus services, operated by Greyhound USA, arrive at Cleveland Bus Station.
Pittsburgh to Cleveland Clinic train services, operated by Amtrak, arrive at Cleveland Amtrak station.
Yes, the driving distance between Pittsburgh to Cleveland Clinic is 127 miles. It takes approximately 2h 20m to drive from Pittsburgh to Cleveland Clinic.
There are 716+ hotels available in Cleveland Clinic.





