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How to get fromPittsburgh to Des Moinesby plane, train, bus, bus (Greyhound), car, or bus (Flixbus, Greyhound)

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There are 7 ways to get from Pittsburgh to Des Moines by plane, train, bus, bus (Greyhound), car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Pittsburgh International Airport

    best
    1. Fly from Pittsburgh International Airport (PIT) to Des Moines (DSM)plane plane PIT - DSM
    6h 9m
    $109–514

  2. Train, bus

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    17h 25m
    $168–363

  3. Bus (Greyhound)

    1. Take the bus from Pittsburgh Intermodal Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Des Moinesbus bus Greyhound US0157S
    18h 40m
    $128–210

  4. Drive  775.6 mi

    1. Drive from Pittsburgh to Des Moinescar car 775.6 mi
    12h 50m
    $142–205

  5. Train to Cleveland-Hopkins International Airport, fly

    1. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Des Moines (DSM)plane plane CLE - DSM
    8h 38m
    $135–586

  6. Train, bus via Galesburg

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    3. Take the bus from Galesburg to Des Moinesbus bus
    19h 17m
    $188–428

  7. Bus via Chicago

    1. Take the bus from Pittsburgh Intermodal Station to Chicagobus bus FlixBus N2640
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    19h 55m
    $135–209

Pittsburgh to Des Moines by train, foot, and bus

Calendar7Weekly Services
Duration17h 25mAverage Duration
Ticket$168Cheapest Price
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Comparing Your Travel Options

Map of how to get from Pittsburgh to Des Moines.ExpandLaunch map view
  • Distance: 733.1 mi
  • Duration: 6h 9m

What companies run services between Pittsburgh, PA, USA and Des Moines, IA, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Pittsburgh International Airport (PIT) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Pittsburgh Intermodal Station to Des Moines via Indianapolis Union Station in around 18h 40m.

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Need to know: Greyhound

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