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How to get fromPittsburgh to Florenceby plane, bus (Greyhound, Flixbus), train (Amtrak), car, bus, or train

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There are 6 ways to get from Pittsburgh to Florence by plane, bus (Greyhound, Flixbus), train (Amtrak), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Regional Airport

    best
    1. Fly from Pittsburgh International Airport (PIT) to Florence Regional Airport (FLO)plane plane PIT - FLO
    5h 50m
    $80–399

  2. Bus

    1. Take the bus from Pittsburgh Intermodal Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus
    14h 28m
    $102–202

  3. Train (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Richmond Staples Mill Road Amtrak Stationtrain train Floridian
    2. Take the train from Richmond Staples Mill Road Amtrak Station to Florence Stationtrain train Palmetto / ...
    17h 14m
    $225–461

  4. Drive 544.2 mi

    1. Drive from Pittsburgh to Florencecar car 544.2 mi
    10h
    $100–144

  5. Fly to Myrtle Beach, bus

    1. Fly from Pittsburgh International Airport (PIT) to Myrtle Beach (MYR)plane plane PIT - MYR
    2. Take the bus from Myrtle Beach to Florencebus bus
    6h 30m

  6. Train, bus

    1. Take the train from Pittsburgh Amtrak Station to Raleigh Union Stationtrain train Floridian
    2. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus Greyhound US0642S / ...
    18h 48m
    $219–438

Pittsburgh to Florence by bus

Calendar28Weekly Buses
Duration14h 28mAverage Duration
Ticket$102Cheapest Price
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Questions & Answers

Map of how to get from Pittsburgh to Florence.ExpandLaunch map view
  • Distance: 464.1 mi
  • Duration: 5h 50m

What companies run services between Pittsburgh, PA, USA and Florence, SC, USA?

American Airlines flies from Pittsburgh International Airport (PIT) to Florence Regional Airport (FLO) 5 times a day. Alternatively, you can take a bus from Pittsburgh Intermodal Station to Florence Bus Station via Washington Union Station and Raleigh Bus Station in around 14h 28m.

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