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How to get fromPittsburgh to Isle of Palmsby bus, plane, train, bus (Greyhound, Flixbus), car, or train (Amtrak)

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There are 6 ways to get from Pittsburgh to Isle of Palms by bus, plane, train, bus (Greyhound, Flixbus), car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly

    best
    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Charleston International Airport (CHS)plane plane PIT - CHS
    4h 23m

  2. Drive 654.9 mi

    cheapest
    1. Drive from Pittsburgh to Isle of Palmscar car 654.9 mi
    11h 20m
    $120–173

  3. Bus, train

    1. Take the bus from Pittsburgh Intermodal Station to Washington Union Stationbus bus Greyhound US0164 / ...
    2. Take the train from Washington Union Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    15h 53m
    $256–473

  4. Bus

    1. Take the bus from Pittsburgh Intermodal Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Charleston Bus Stationbus bus
    19h 37m
    $181–318

  5. Train (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Petersburg Amtrak Stationtrain train Floridian
    2. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    19h 5m
    $307–597

  6. Bus, drive

    1. Take the bus from Pittsburgh Intermodal Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Myrtle Beach Bus Stationbus bus
    4. Drive from Myrtle Beach Bus Station to S. Pinckney St / Society Rdcar car
    5. Take the bus from S. Pinckney St / Society Rd to Stuart Engals Blvd / Wando Crossing Centerbus bus
    26h 14m
    $174–314

Pittsburgh International Airport (PIT) to Charleston International Airport (CHS) flights

Calendar59Weekly Planes
Duration3h 30mAverage Duration
Ticket$77Cheapest Price
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Questions & Answers

Map of how to get from Pittsburgh to Isle of Palms.ExpandLaunch map view
  • Distance: 572.3 mi
  • Duration: 4h 23m

What companies run services between Pittsburgh, PA, USA and Isle of Palms, SC, USA?

You can take a bus from Pittsburgh Intermodal Station to Isle of Palms via Washington Union Station, Raleigh Bus Station, and Charleston Bus Station in around 19h 37m. Alternatively, you can take a train from Pittsburgh Amtrak Station to Isle of Palms via Petersburg Amtrak Station and Charleston Amtrak Station in around 19h 5m.

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