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How to get fromPittsburgh to Knoxvilleby plane, train, bus, car, bus (Greyhound), or bus (Flixbus)

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There are 7 ways to get from Pittsburgh to Knoxville by plane, train, bus, car, bus (Greyhound), or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Pittsburgh International Airport to Mcghee Tyson Airport

    best
    1. Fly from Pittsburgh International Airport (PIT) to Mcghee Tyson Airport (TYS)plane plane PIT - TYS
    6h 9m
    $194–809

  2. Drive 487.4 mi

    cheapest
    1. Drive from Pittsburgh to Knoxvillecar car 487.4 mi
    8h 17m
    $89–129

  3. Train, bus

    1. Take the train from Pittsburgh Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Pennsylvanian
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    22h 57m
    $280–448

  4. Fly Pittsburgh International Airport to Nashville, drive

    1. Fly from Pittsburgh International Airport (PIT) to Nashville (BNA)plane plane PIT - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 31m
    $669–1,063

  5. Bus to Morgantown Municipal Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Pittsburgh Greyhound to Westover Terminalbus bus
    2. Fly from Morgantown Municipal Airport (MGW) to Mcghee Tyson Airport (TYS)plane plane MGW - TYS
    8h 46m
    $179–751

  6. Bus via Farragut

    1. Take the bus from Pittsburgh Intermodal Station to Port Authority Bus Terminalbus bus Greyhound US0421 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    23h 17m
    $256–389

  7. Bus

    1. Take the bus from Pittsburgh Intermodal Station to New York City Chinatownbus bus FlixBus N2640
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    26h 30m
    $172–233

Pittsburgh International Airport (PIT) to Mcghee Tyson Airport (TYS) flights

Calendar125Weekly Planes
Duration4h 29mAverage Duration
Ticket$138Cheapest Price
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Questions & Answers

Map of how to get from Pittsburgh to Knoxville.ExpandLaunch map view
  • Distance: 420.4 mi
  • Duration: 6h 9m

What companies run services between Pittsburgh, PA, USA and Knoxville, TN, USA?

Delta, Southwest Airlines, and two other airlines fly from Pittsburgh International Airport (PIT) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Pittsburgh Intermodal Station to Knoxville via Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 23h 17m.

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