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How to get fromPittsburgh to Knoxvilleby plane, bus, car, train, or bus (Flixbus)

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There are 7 ways to get from Pittsburgh to Knoxville by plane, bus, car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Pittsburgh International Airport (PIT) to Mcghee Tyson Airport (TYS)plane plane PIT - TYS
    5h 53m
    $255–1,216

  2. Drive  487.4 mi

    cheapest
    1. Drive from Pittsburgh to Knoxvillecar car 487.4 mi
    8h 17m
    $89–129

  3. Bus via Farragut

    1. Take the bus from Pittsburgh Greyhound to Port Authority Bus Terminalbus bus New York / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    21h 27m
    $234–333

  4. Fly to Nashville, drive

    1. Fly from Pittsburgh International Airport (PIT) to Nashville (BNA)plane plane PIT - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 33m
    $516–1,125

  5. Fly to Greenville–Spartanburg International Airport, drive

    1. Fly from Pittsburgh International Airport (PIT) to Greenville–Spartanburg International Airport (GSP)plane plane PIT - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Knoxvillecar car
    7h
    $148–763

  6. Train, bus

    1. Take the train from Pittsburgh Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Pennsylvanian
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    22h 57m
    $378–532

  7. Bus

    1. Take the bus from Pittsburgh Intermodal Station to New York City Chinatownbus bus FlixBus N2640
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    26h 30m
    $171–220

Pittsburgh International Airport (PIT) to Mcghee Tyson Airport (TYS) flights

Calendar101Weekly Planes
Duration4h 6mAverage Duration
Ticket$199Cheapest Price
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Comparing Your Travel Options

Map of how to get from Pittsburgh to Knoxville.ExpandLaunch map view
  • Distance: 420.4 mi
  • Duration: 5h 53m

What companies run services between Pittsburgh, PA, USA and Knoxville, TN, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Pittsburgh International Airport (PIT) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Pittsburgh Greyhound to Knoxville via Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 21h 27m.

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